【摘要】 目的分析血清肝细胞生长因子(HGF)、白细胞介素-6(IL-6)水平预测原发性肝癌(PHC)患者经肝动脉化疗栓塞术(TACE)治疗预后的价值。方法选取新乡医学院第一附属医院肝胆胰外科2018年11月至2020年11月收治的65例PHC患者为研究对象,均接受TACE治疗,治疗后对所有患者至少随访4周,参照实体瘤RECIST 1.0评估患者短期预后情况,并分为预后不良组和预后良好组;检测患者治疗前血清HGF、IL-6水平,分析血清HGF、IL-6水平预测PHC患者TACE治疗预后不良的价值。结果 65例PHC患者经评估,预后不良14例,占21.54%;预后不良组治疗前血清HGF、IL-6水平高于预后良好组,差异有统计学意义(P<0.05);绘制受试者工作曲线结果显示,血清HGF、IL-6水平单独及联合预测PHC患者TACE治疗预后不良的曲线下面积分别为0.824、0.837、0.876,均有一定的预测价值,且联合检测预测价值最高。结论血清HGF、IL-6水平对预测PHC患者TACE治疗具有一定的价值,血清HGF、IL-6过表达提示患者预后不良的风险较高。更多还原

【Abstract】 Objective To analyze the prediction value of serum hepatocyte growth factor(HGF) and interleukin-6(IL-6) levels for prognosis of patients with primary liver cancer(PHC) after transcatheter arterial chemoembolization(TACE).Methods Sixty-five patients with PHC treated in the Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital of Xinxiang Medical College from November 2018 to November 2020 were selected as the research subjects, all patients were treated with TACE and followed up for at least 4 weeks after treatment, according to RECIST 1.0 of solid tumor, the short-term prognosis of patients was evaluated and divided them into poor prognosis group and good prognosis group. The levels of serum HGF and IL-6 of patients were measured before treatment, the value of serum HGF and IL-6 levels in predicting the poor prognosis of PHC patients treated with TACE was analyzed.Results The prognosis of 65 patients with PHC after assessment was poor in 14 cases, accounting for 21.54%. The levels of serum HGF and IL-6 in the poor prognosis group were higher than those in the good prognosis group(P<0.05). The receiver operating curve was drawn, and the results showed that the area under the curve of serum HGF and IL-6 levels alone and combined to predict the poor prognosis of PHC patients treated with TACE were 0.824, 0.837 and 0.876, respectively, all of them had certain predictive value, and the predictive value of joint detection was the highest.Conclusion Serum HGF and IL-6 levels have certain value in predicting TACE treatment in PHC patients, the overexpression of serum HGF and IL-6 suggests that patients are at high risk of poor prognosis.更多还原