【摘要】 目的探讨妊娠糖尿病(GDM)孕妇维生素D缺乏与血糖状态的关系。方法选取2019年6月至2020年6月于郑州大学第五附属医院产前检查的100例孕妇作为研究对象,第24～28周被诊断为GDM的50名孕妇为GDM组,无任何葡萄糖不耐受的50名孕妇为对照组。入组时对患者进行详细的病史记录、全面体检,分别检测空腹血糖(FBG)、血清25-[OH]-D水平、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、稳态模型的胰岛素抵抗指数(HOMA-IR)。结果 GDM组患者的FBG、FINS、HOMA-IR和HbA1c高于正常组(P<0.05)。在GDM患者中,维生素D与HbA1c、FINS和HOMA-IR呈负相关。GDM组患者和对照组的平均维生素D水平差异有统计学意义(P<0.05)。结论 GDM女性血清25-[OH]-D水平降低,维生素D缺乏与GDM患者的HbA1c、FINS和HOMA-IR之间存在相关性。更多还原

【Abstract】 Objective To investigate the relationship between vitamin D deficiency and blood glucose status in pregnant women with gestational diabetes mellitus(GDM).Methods A total of 100 pregnant women who underwent prenatal examination in the Fifth Affiliated Hospital of Zhengzhou University from June 2019 to June 2020 were selected as the study subjects. Fifty pregnant women who were diagnosed with GDM at 24 to 28 weeks were selected as the GDM group, and 50 pregnant women without any glucose intolerance were selected as the control group. Detailed medical history and comprehensive physical examination were performed for each patient at the time of enrollment. Fasting blood glucose(FBG), serum 25-[OH]-D level, glycosylated hemoglobin(HbA1 c), fasting insulin(FINS) and homeostasis model assessment of insulin resistance(HOMA-IR) were detected respectively.Results FBG, FINS, HOMA-IR and HbA1 c in GDM group were higher than those in control group(P<0.05). In patients with GDM, vitamin D was found to be negatively correlated with HbA1 c, serum FINS and HOMA-IR, and there was difference in mean vitamin D levels between GDM group and control group.Conclusion Serum 25-[OH]-D levels in women with GDM are decreased, and vitamin D deficiency is correlated with FINS, HbA1 c, and HOMA-IR in patients with GDM.更多还原