【摘要】 目的探讨糖原合成酶激酶-3β(GSK-3β)、正五聚蛋白3(PTX3)水平与急性脑梗死患者神经功能及血流动力学的相关性。方法选取2018-01—2019-12商丘市中心医院治疗的急性脑梗死患者110例为观察组,同时选取健康体检者100例为对照组,采用WB法检测血浆GSK-3β表达,采用免疫吸附法检测PTX3表达,检测脑循环血流速度、血流量和外周阻力。结果观察组外周血GSK-3β表达、PTX3明显高于对照组(P<0.05);观察组脑循环血流速度和血流量明显低于对照组(P<0.05),而外周阻力明显高于对照组(P<0.05);观察组NIHSS评分≥21分患者外周血GSK-3β表达、PTX3明显高于NIHSS评分<5分和5～20分患者(P<0.05);GSK-3β表达、PTX3与NIHSS评分呈正相关(r=0.592和0.444,P<0.05);GSK-3β表达、PTX3与脑循环外周阻力呈正相关(r=0.466和0.453,P<0.05)。结论急性脑梗死患者外周血GSK-3β、PTX3水平升高,与神经功能受损、脑循环外周阻力呈正相关。更多还原

【Abstract】 Objective To investigate the correlation between the levels of glycogen synthase kinase-3β (GSK-3β) and pentamogen 3(PTX3)and the neurological function and hemodynamics of patients with acute cerebral infarction. Methods A total of 110 patients with acute cerebral infarction from January 2018 to December 2019 were selected, and 100 healthy people were selected as the control group, the expression of GSK-3β in plasma was detected by WB method, the expression of PTX3 was detected by immunoadsorption method, and the blood flow velocity, blood flow and peripheral resistance of cerebral circulation were detected.Results The expression of GSK-3β and PTX3 in the peripheral blood of the observation group h were significantly higher than that of the control group(P < 0.05). The cerebral circulation velocity and blood flow of the observation group were significantly lower than those of the control group(P < 0.05), while the peripheral resistance was significantly higher than those of the control group(P < 0.05);The expression of GSK-3β and PTX3 in the patients with NIHSS score ≥ 21 were significantly higher than those with NIHSS score < 5 and 5-20(P < 0.05). GSK-3β expression and PTX3 were positively correlated with NIHSS score(r = 0.592 and0.444, P < 0.05);GSK-3β expression and PTX3 were positively correlated with peripheral resistance of cerebral circulation(r =0.466 and 0.453, P < 0.05). Conclusion The levels of GSK-3β and PTX3 in peripheral blood of patients with acute cerebral infarction are increased, which is positively correlated with neurological impairment and peripheral resistance of cerebral circulation.更多还原