【摘要】 目的探讨术前预康复改善食管胃结合部腺癌患者围术期身体功能及营养指标的效果。方法将168例患者按手术时间先后分为对照组与预康复组各84例。于术前9～11周新辅助化疗期间,对照组行常规围术期护理;预康复组实施术前预康复方案,包括运动预康复(有氧运动,阻力训练,肺功能锻炼)和营养支持(改善疾病相关症状,优化身体素质,平衡饮食)。结果对照组75例、预康复组80例完成全程研究。术前1 d及术后4周预康复组6分钟步行距离,血清白蛋白、前白蛋白值显著优于对照组(均P<0.01);术后白蛋白输入量、肺部感染率显著少于/低于对照组(P<0.05,P<0.01)。结论对手术联合新辅助化疗的食管胃结合部腺癌患者,行术前预康复可改善围手术期身体功能和营养状态,有利于患者完成全程治疗。更多还原

【Abstract】 Objective To investigate the effect of preoperative prehabilitation on functional status and nutritional status of patients with adenocarcinoma of the esophagogastric junction(AEG). Methods One hundred and sixty-eight patients with AEG were divi-ded into a control group and a prehabilitation group according to operation time, with 84 in each group. During 9 to 11 weeks of preoperative neoadjuvant chemotherapy, the control group received routine nursing care, while the prehabilitation group was subjected to preoperative prehabilitation program, including exercise prehabilitation(aerobic exercise, resistance training, and respiratory exercise) and nutritional support(ameliorating disease-related symptoms, optimizing physical fitness, and balanced diet). Results A total of 75 patients in the control group and 80 in the prehabilitation group completed the study. The 6-minute walk distance, serum albumin and prealbumin on preoperative day 1 and at postoperative week 4 in the prehabilitation group were significantly higher than those in the control group(P<0.01 for all). Intravenous infusion of albumin and pulmonary infection rate after the operation were significantly lower in the prehabilitation group compared with the control group(P<0.05, P<0.01). Conclusion Preoperative prehabilitation can improve physical function and nutritional status of patients with AEG undergoing radical ope-ration in combination with neoadjuvant chemotherapy, which is conducive to completion of the whole treatment.更多还原