【摘要】 目的:研究硫酸羟氯喹治疗干燥综合征(SS)的疗效及对患者血清白介素-17(IL-17)、红细胞沉降率(ESR)、C反应蛋白(CRP)和免疫球蛋白G(IgG)水平的影响。方法:将2017年3月至2020年3月我院194例SS患者随机均分为观察组和对照组各97例,两组均在对症治疗基础上给予加甲泼尼龙口服,观察组另加用硫酸羟氯喹口服治疗,疗程均为3个月,观察两组治疗效果和不良反应,同时检测治疗前后泪液分泌试验(ST),唾液流率(SFR)及血清IL-17、ESR、CRP和IgG水平变化。结果:观察组治疗效果明显优于对照组(P<0.05),两组有效率分别为86.60%和75.26%(P<0.05);两组治疗前ST和SFR比较无明显差异(P>0.05),治疗后ST和SFR均明显升高(P<0.05),且观察组ST和SFR治疗前后差值高于对照组,差异有统计学意义(P<0.05);两组治疗前血清IL-17、ESR、CRP和IgG水平比较无明显差异(P>0.05),治疗后血清IL-17、ESR、CRP和IgG水平均明显降低(P<0.05),且观察组IL-17、ESR、CRP和Ig G治疗前后差值高于对照组,差异有统计学意义(P <0.05);观察组和对照组不良反应发生率分别为16.49%和12.37%(P>0.05)。结论:硫酸羟氯喹辅助治疗SS可有效降低血清IL-17、ESR、CRP和IgG水平,从而改善患者症状并提升治疗效果。更多还原

【Abstract】 Objective: To study the efficacy of hydroxychloroquine sulfate in the treatment of Sjogren’s syndrome( SS) and the effects on levels of serum interleukin-17( IL-17),erythrocyte sedimentation rate( ESR),C-reactive protein( CRP) and immunoglobulin G( IgG). Methods: A total of 194 SS patients admitted to our hospital from March 2017 to March 2020 were randomly and evenly divided into observation group and control group,with 97 cases in each group. Both groups were given methylprednisolone on the basis of symptomatic treatment,and observation group was additionally given hydroxychloroquine sulfate during treatment,and the treatment lasted 3 months. The treatment effects and adverse reactions were observed in the two groups,and the Schirmer Test( ST),salivary flow rate( SFR) and levels of serum IL-17,ESR,CRP and Ig G were detected before and after treatment. Results: The treatment effects in observation group were significantly better than those in control group( P <0.05),and the effective rates of the two groups were 86.60%and 75.26%( P <0.05). There were no significant differences in ST and SFR between the two groups before treatment( P >0.05). After treatment,ST and SFR were significantly increased( P < 0. 05),and the differences of ST and SFR in observation group after treatment were higher than those in control group( P <0.05).There were no significant differences in the levels of serum IL-17,ESR,CRP and IgG between the two groups before treatment( P >0.05). After treatment,the levels of serum IL-17,ESR,CRP and IgG were significantly reduced( P <0.05),and the differences of IL-17,ESR,CRP and IgG before and after treatment in observation group were higher than those in control group( P <0.05). The incidence rates of adverse reactions in observation group and control group were 16.49% and 12.37% respectively( P > 0.05). Conclusion: Hydroxychloroquine sulfate in the adjuvant treatment of SS can effectively reduce the levels of serum IL-17,ESR,CRP and Ig G,thereby improving the symptoms and enhancing the treatment effects.更多还原