【摘要】 以L-脯氨酸和氯乙酰氯为原料合成维格列汀的重要中间体（S）-1-（2-氯乙酰基）吡咯烷-2-甲酸（1）。甲醇体系室温挥发14 d培养得到1的无色透明块状晶体,通过单晶X-射线衍射技术对其进行结构解析。结果表明1晶胞属于正交晶系,P2₁2₁2₁空间群,分子式为C₇H₁₀NO₃Cl,相对分子质量为191.61 g/mol,立体构型和预测构型一致,确证了1的空间结构。更多还原

【Abstract】 (S)-1-（2-chloroacetyl）pyrrolidine-2-carboxylic acid（1） is an important intermediate of vildagliptin, synthesized from L-proline and chloroacetyl chloride as raw materials. The title compound 1 colorless transparent massive crystal has been grown by evaporation in methanol for 14 d at room temperature. Then, the crystal structure was solved by single crystal X-ray diffraction（SCXRD） analysis. SCXRD confirmed the orthorhombic lattice with space group P2₁2₁2₁ in 1 crystal. Moreover, the chemical formula and relative molecular mass were C₇H₁₀NO₃Cl and 191.61 g/mol, respectively. The measured crystal structure was in good agreement with the predicted one, confirming the single crystal structure of 1.更多还原