【摘要】 目的探讨利拉鲁肽治疗2型糖尿病伴肥胖患者对体重指数、血糖水平、微炎症水平及脂质水平的干预作用。方法选择2017年1月至2019年1月内分泌科治疗的2型糖尿病伴肥胖患者81例,随机分为对照组40例和观察组41例。对照组口服二甲双胍片治疗,观察组在对照组基础上使用皮下注射利拉鲁肽治疗,连续治疗12周后,对比2组的体质指标、血糖各指标、微炎症指标、脂质指标。结果 2组治疗前腰围、臀围、腰臀比、BMI差异无统计学意义(P>0.05),观察组治疗12周后腰围、臀围、BMI明显小于对照组,而腰臀比明显大于对照组(P<0.05);观察组治疗12周后FPG、2 h PG、HbA1c、HOMA-IR均低于对照组(P<0.05);观察组治疗12周后AASA、IL-6、TNF-α水平明显低于对照组(P<0.05);观察组治疗12周后TC、TG、LDL-C水平明显低于对照组,而HDL-C水平明显高于对照组(P<0.05)。结论利拉鲁肽治疗2型糖尿病伴肥胖患者具有良好效果,能够有效降糖、降脂、降低体重指数(BMI)、减轻微炎症水平,有助于改善病情结局,具有积极的临床意义。更多还原

【Abstract】 Objective To investigate the intervention effects of liraglutide in treatment of type 2 diabetes mellitus patients with obesity and its effects on the body mass index, blood glucose level, micro-inflammation and lipid levels.Methods A total of 81 patients with type 2 diabetes mellitus complicated by obesity who were treated in our hospital from January 2017 to January 2019 were randomly divided into control group(n=40) and observation group(n=41).The patients in control group were treated by oral metformin tablets, however, the patients in observation group, on the basis of control group, were treated by subcutaneous injection of liraglutide, with a treatment course of 12 weeks for both groups. The body mass indexes [waistline, hip circumference, waist hip ratio, body mass index(BMI),blood sugar each indexes [fasting plasma glucose(FPG),2 h postprandial blood glucose(2 hPG),glycosylated hemoglobin(HbA1 c),insulin resistance indexes(HOMA IR)],micro inflammation indexes [serum amyloid protein A(AASA),interleukin 6(IL-6),tumor necrosis factor alpha(TNF alpha)],lipid indexes [total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)]were observed and compared between the two groups.Results Before treatment there were no significant differences in waist circumference, hip circumference, waist-to-hip ratio and BMI between the two groups(P>0.05).After 12 week-treatment, the waist circumference, hip circumference and BMI in observation group were significantly lower than those in control group, however, the waist-to-hip ratio was significantly higher than that in control group(P<0.05).And the levels of FPG,2 hPG,HbA1 c, HOMA-IR and AASA,IL-6,TNF-α as well as TC,TG,LDL-C in observation group were significantly lower than those in control group(P<0.05),however, the HDL-C levels were significantly higher than those in control group(P<0.05).Conclusion The liraglutide has obvious effects in treatment of type 2 diabetes mellitus complicated by obesity, which can effectively decrease sugar, fat, BMI,and reduce the microinflammation levels, which is helpful to improve the outcome of the disease, and has positive clinical significance.更多还原