【摘要】 目的探讨利拉鲁肽对肥胖型糖尿病患者空腹血糖、餐后2 h血糖、糖化血红蛋白水平产生的影响。方法选择2017年1月至2019年1月治疗的肥胖型2型糖尿病患者81例,随机分为2组,对照组40例使用二甲双胍治疗,在此基础上观察组41例使用利拉鲁肽治疗,治疗12周后,对比2组的临床疗效、空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)、体重指数(BMI)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)变化,血脂指标(TC、TG、HDL-C、LDL-C)变化,生活质量(SF-36量表)变化。结果观察组治疗有效率为95.12%明显高于对照组的75.00%(P<0.05);2组治疗前FPG、2 hPG、HbA1c、BMI、FINS、HOMA-IR水平差异无统计学意义(P>0.05),观察组治疗后12周后的FPG、2hPG、HbA1c、BMI、HOMA-IR水平明显低于对照组,而FINS水平明显高于对照组(P<0.05);2组治疗前TC、TG、HDL-C、LDL-C水平差异无统计学意义(P>0.05),观察组治疗后12周后的TC、TG、LDL-C水平明显低于对照组,而HDL-C水平明显高于对照组(P<0.05);2组治疗前社会功能、角色功能、认知功能、躯体功能等SF-36评分差异无统计学意义(P>0.05),观察组治疗后12周后的社会功能、角色功能、认知功能、躯体功能等SF-36评分明显高于对照组(P<0.05)。结论利拉鲁肽对肥胖型糖尿病患者有良好的治疗效果,能有效控制血糖及血脂,降低FPG、2 h PG、HbA1c及BMI,有助于改善机体的健康状况,减轻代谢紊乱,具有积极的临床意义。更多还原

【Abstract】 Objective To investigate the effects of liraglutide on fasting blood glucose, 2 h postpranital blood glucose and glycosylated hemoglobin in patients with obese type 2 diabetes mellitus(T2 DM).Methods A total of 81 patients with obese T2 DM who were treated in our hospital from January 2017 to January 2019 were enrolled in the study, who were randomly divided into control group(n=40) and observation group(n=41).The patients in control group were treated by metformin, however, the patients in observation group, on the basis of control group, were treated by liraglutide.After 12-week treatment, the clinical curative effects, and the changes of fasting plasma glucose(FPG),2 h postprandial blood glucose(2 HPG),glycosylated hemoglobin(HbA1 c),body mass index(BMI),fasting insulin(FINS),insulin resistance index(HOMA IR),and blood lipid indexes(TC,TG,HDL-C,LDL-C) and life quality(SF-36 rating scales) were observed and compared between the two groups.Results The effective rate in observation group was 95.12%,which was significantly higher than that(75.00%) in control group(P<0.05).Before treatment there were no significant differences in the levels of FPG,,2 hPG,HbA1 c, BMI,FINS,HOMA-IR between the two groups(P>0.05).After 12-week treatment the levels of FPG,2 hPG,HbA1 c, BMI,HOMA-IR in observation group were significantly lower than those in control group, however, the FINS levels were significantly higher than those in control group(P<0.05).Before treatment there were no significant differences in the levels of TC,TG,HDL-C,LDL-C between the two groups(P>0.05).After 12-week treatment the levels of TC,TG,LDL-C in observation group were significantly lower than those in control group, however, the HDL-C levels were significantly higher than those in control group(P<0.05).Before treatment there were no significant differences in SF-36 scores including social function, role function, cognitive function and somatic function between the two groups(P>0.05).After 12-week treatment the SF-36 scores in observation group were significantly higher than those in control group(P<0.05).Conclusion The liraglutide has better therapeutic effects on obese T2 DM,which can effectively control blood glucose and blood lipid, decrease the levels of FPG,2 hPG,HbA1 c and BMI,improve the health status of the body, relieve the metabolic disorders, which has positive clinical significance.更多还原