【摘要】 目的探究维生素A、C联合琥珀酸亚铁叶酸片对子癫前期的预防效果。方法选择高危子痫前期风险的孕妇152例为研究对象,按随机数表分为观察组和对照组各76例,两组产妇均接受围生期常规检查和保健护理,对照组孕妇在常规护理基础上给予安慰剂治疗,观察组在常规护理基础上给予维生素A、C联合琥珀酸亚铁叶酸片治疗。比较两组孕妇治疗前后血压[收缩压(SBP)、舒张压(DBP)]、胎盘血流动力学指标[搏动指数(PI)、阻力指数(RI)、收缩末期血流速度与舒张末期血流速度比(S/D)]、子痫前期发生率及母婴结局差异。结果治疗后两组孕妇SBP、DBP、PI、RI、S/D水平较治疗前均显著降低(P<0.05),且观察组明显低于同期对照组(P<0.05);观察组孕妇子痫前期、胎盘早剥、新生儿窒息发生率明显低于对照组(P<0.05),新生儿Apgar评分明显高于对照组(P<0.05)。结论维生素A、C联合琥珀亚铁叶酸片能改善孕妇血压和胎盘血流动力学,有效预防子痫前期发生,有利于良好母婴结局。更多还原

【Abstract】 Objective To explore the preventive effect of vitamin A and C combined with ferrous succinate and folic acid tablets on preeclampsia.Methods 152 pregnant women with high risk of preeclampsia from October 2016 to October 2019 in our hospital were selected as the research objects.According to the random number table,they were divided into observation group and control group with 76 cases each.Both groups of parturients received routine perinatal examination and health care.The control group received placebo treatment on the basis of routine care,and the observation group received vitamin A and C combined with ferrous succinate and folic acid tablets on the basis of routine care.The differences in blood pressure(SBP,DBP),placental hemodynamic indexes(PI,RI,S/D),preeclampsia incidence,and maternal and infant outcomes between the two groups of pregnant women before and after treatment were compared.Results After treatment,the levels of SBP,DBP,PI,RI,and S/D of pregnant women in the two groups were significantly lower than before treatment(P<0.05),and the observation group was significantly lower than the control group during the same period(P<0.05).The incidence of preeclampsia,placental abruption,and neonatal asphyxia in the observation group was significantly lower than that of the control group(P<0.05),and the Apgar score of newborns was significantly higher than that of the control group(P<0.05).Conclusion Vitamin A and C combined with succinate folic acid tablets can improve pregnant women’s blood pressure and placental hemodynamics,effectively prevent the occurrence of preeclampsia,and contribute to good maternal and infant outcomes.更多还原