【摘要】 目的探究高危型HPV感染、宫颈细胞学(TCT)检测与中山市妇女宫颈病变之间的相关性。方法选择医院接受治疗的HPV阳性患者2756例,均行薄层液基细胞学(TCT)检测、高危型HPV检查和宫颈活检组织病理学诊断。以组织病理学诊断为金标准,研究三者之间的关系。结果 2756例HPV感染阳性患者中,TCT检查宫颈疾病阳性者383例,占13.90%,其中有112例患者为高危型16/18HPV,阳性率为29.24%。各组的高危型HPV16/18感染率比较,差异有统计学意义(P<0.05)。HSIL组的高危型HPV感染率明显高于LSIL组(P<0.05)。不同宫颈疾病的TCT检测阳性率由高到低依次为宫颈癌、HSIL、LSIL、宫颈炎及未见异常(P<0.05)。TCT与高危型HPV联合检测的阳性符合率明显高于单一TCT、高危型HPV检测(P<0.05);单一TCT检测、高危型HPV检测及联合检测不同宫颈疾病的阳性符合率由高到低依次为宫颈癌、HSIL和LSIL(P<0.05)。结论高危型HPV持续感染为宫颈癌及宫颈癌前病变的重要病因,TCT和高危型HPV联合检测有利于宫颈病变的早期诊断。更多还原

【Abstract】 Objective To explore the correlation between high-risk HPV infection,thinprep cytology test detection and cervical lesions in women in Zhongshan city.Methods 2756 HPV positive patients were selected as the study subjects,which all patients underwent thinprep cytology test,HPV and pathological examination.The pathological examination was used as the gold standard to study the relationship among the three.Results The positive rate of cervical lesions detected by TCT was 13.90%,and there were 112 patients with high-risk HPV16/18 type accounting for 29.24%.There were significant difference in the infection rate of high-risk HPV detected by TCT in each group(P<0.05).The high-risk HPV infection rate in HSIL group was higher than that in LSIL group(P<0.05).The positive rates of TCT detection for different cervical lesions from high to low were cervical cancer,HSIL,LSIL,cervicitis and no abnormal(P<0.05).The positive coincidence rate of TCT and high-risk HPV combined test was higher than that of single TCT or high-risk HPV test(P<0.05).The positive coincidence rates of single TCT test,high-risk HPV test and combined test for different cervical lesions from high to low were cervical cancer,HSIL and LSIL(P<0.05).Conclusion Persistent infection of high-risk HPV is the main pathogenic factor for cervical cancer and cervical lesions,and the combined detection of TCT and high-risk HPV is conducive to the early diagnosis of cervical lesions.更多还原