【摘要】 药食同源植物活性物质具有多环节、多层次、多靶点特点,其发展为降尿酸药物减毒增效及辅助治疗高尿酸食品开发提供新思路。基于嘌呤代谢和尿酸产生途径,概述了高尿酸血症化学合成药物治疗情况,对植源性天然产物提取和高尿酸血症动物模型建造现状进行梳理;从抑制尿素合成、促进尿酸排泄、肾保护作用及减轻炎症等方面分析了典型药食同源植物活性物质调节尿酸代谢途径;最后对药食同源植物活性物质未来发展趋势进行展望。更多还原

【Abstract】 Medicinal and food homologous plant active substances have the characteristics of multi-link, multi-level and multi-target, and their development provides a new idea for the development of food which can reduce the toxicity and increase the efficacy of uric acid lowering drugs and play the role of adjuvant therapy.Based on purine metabolism and uric acid production pathways, this paper summarized the treatment of hyperuricemia chemosynthetic drugs, extraction of plant-derived natural products and the construction of animal models of hyperuricemia.In order to inhibit urea synthesis, promote uric acid excretion, protect kidney and reduce inflammation, the regulation of uric acid metabolism by typical plant active substances from food and medicine was analyzed.Finally, the future development trend of medicinal and food homologous plant active substances was prospected.更多还原