【摘要】 目的:探讨慢性心力衰竭(CHF)患者脑钠肽(BNP)、肌钙蛋白Ⅰ(cTnⅠ)、同型半胱氨酸(Hcy)表达水平与室性心律失常(VA)的相关性。方法:选取2016年7月至2019年6月云浮市人民医院收治的60例CHF伴VA患者作为观察组,另选取42例同期体检健康者作为对照组。根据Lown法对VA患者分级,比较各组BNP、cTnⅠ、Hcy水平差异,并对BNP、cTnⅠ、Hcy的表达与VA的相关性进行分析。结果:观察/mL、(0.51±0.14)ng/mL、(23.62±5.41)μmol/L],显著高/mL、(0.05±0.01)ng/mL、(9.24±2.89)μmol/L](P<0.01);随着VA分级的增加,CHF患者BNP、cTnⅠ水平呈上升趋势,其中Ⅳ～Ⅴ级BNP、cTnⅠ水平高于Ⅱ～Ⅲ级及Ⅰ级(P<0.05)。观察组BNP与cTnⅠ、Hcy水平均呈正相关(rs=0.512,rs=0.724,P<0.05),cTnⅠ与Hcy水平呈正相关(rs=0.427,P<0.05);观察组BNP、Hcy水平与VA无显著相关(P>0.05),cTnⅠ与VA呈中等程度相关(rs=0.412,P<0.05)。结论:CHF伴VA患者BNP、cTnⅠ、Hcy水平高于正常,随Lown分级增加BNP、cTnⅠ呈上升趋势;cTnⅠ与VA呈正相关。更多还原

【Abstract】 Objective:To investigate the correlation among the expression of brain natriuretic peptide(BNP),cardiac troponin Ⅰ(cTnⅠ)and homocysteine(Hcy),and ventricular arrhythmia(VA)in patients withchronic heart failure(CHF).Methods:Sixty CHF patients with VA admitted to Yunfu People’s Hospital betweenJuly 2016 and June 2019 were enrolled as the study group,and a contemporary cohort of 42 healthy check-upsubjects were selected as the control group.The VA in the patients were graded according to Lown classification.The levels of BNP,cTnⅠ,and Hcy were compared among the study group and the control group,as well as amongpatients with different Lown classifications.The correlation among the expression levles of BNP,cTnⅠ,and Hcy,and VA,was analyzed.Results:The levels of BNP,cTnⅠ and Hcy in the study group were(428.74±132.19)pg/mL,(0.51±0.14)ng/mL,and(23.62±5.41)μmol/L,which were significantly higher than those in the controlgroup[(58.36)±12.62)pg/mL,(0.05±0.01)ng/mL,(9.24±2.89)μmol/L,respectively](P< 0.01).Withhigher VA class,the levels of BNP and cTnⅠ in the CHF patients showed an upward trend.The levels of BNP andcTnⅠ were higher in patients with classes IV-V VA than those with classes Ⅱ-Ⅲ or class Ⅰ VA(P<0.05).In thestudy group,BNP was positively correlated with cTnⅠ and Hcy levels(rs= 0.512,rs= 0.724,P<0.05);cTnⅠ waspositively correlated with Hcy level( rs= 0. 427,P < 0. 05). In the study group,the BNP and Hcy did notsignificantly correlated(P>0.05),whereas the cTnⅠ was moderately correlated(rs= 0.412,P<0.05),with VA.Conclusion:In CHF patients with VA,the levels of BNP,cTnⅠ,and Hcy are higher than normal;BNP and cTnⅠ tend to increase with the higher Lown classification;cTnⅠ is positively correlated with VA.更多还原