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药用天然产物生物合成途径研究进展
Research Progress on Biosynthetic Pathways of Medicinal Natural Products
【摘要】 近年来随着天然产物井喷式的发现,越来越多的具有良好生物活性的天然产物被开发成药物。例如免疫抑制剂霉酚酸、降胆固醇药物洛伐他汀,抗寄生虫药物阿维菌素、抗疟疾药物青蒿素、抗肿瘤药物紫杉醇等。药用天然产物在人类的生产生活中的地位越来越重要。真菌来源天然产物是药用天然产物中的一大类,许多重要的药用天然产物来源于真菌,例如霉酚酸、洛伐他汀,夫西地酸等。
【Abstract】 In recent years, with the discovery of natural product blowout, more and more natural products with good biological activity have been developed into drugs, for example, the immunosuppressant mycophenolic acid, the cholesterol-lowering drug lovastatin, the antiparasitic drug avermectin, the antimalarial drug artemisinin, and the antitumor drug paclitaxel. The status of medicinal natural products in human production and life is becoming more and more important. Fungal-derived natural products are a large class of medicinal natural products, and many important medicinal natural products are derived from fungi such as mycophenolic acid, lovastatin, fusidic acid.
【Key words】 medicinal natural products; natural products of fungi; biosynthetic pathways;
- 【文献出处】 广州化工 ,Guangzhou Chemical Industry , 编辑部邮箱 ,2021年20期
- 【分类号】R915
- 【下载频次】1002