【摘要】 通过比较浓硫酸与氧化铝为催化剂对阿司匹林合成的影响后,采用L₉（3⁴）的正交试验优化氧化铝催化阿司匹林合成的工艺条件。当氧化铝用量为水杨酸的20%,控制温度90℃,反应时间35 min,水杨酸与乙酸酐的摩尔比为1:2.67时,产率为63.44%。氧化铝可代替浓硫酸催化阿司匹林的合成。本法为生产提供一种经济、环境友好型的催化剂,并为《药物化学实验》教学中学生创新性能力培养提供良好的基础。更多还原

【Abstract】 The effects of concentrated sulfuric acid and alumina as catalyst on the synthesis of aspirin were compared. Then the synthetic conditions were optimized by orthogonal test of L₉（3⁴）. The results showed that the catalytic effect of alumina was better than that of concentrated sulfuric acid, the yield was 63.44% when the weight ratio of alumina to salicylic acid was 20%, the temperature was 90 ℃, the reaction time was 35 min and the molar ratio of salicylic acid to acetic anhydride was 1:2.67. It provided an economical and environmentally friendly catalyst for aspirin production, and provided a good foundation for cultivating students’ innovative ability in Pharmaceutical Chemistry experiment teaching.更多还原