【摘要】 目的探究中山市宫颈鳞状上皮内病变患者人乳头瘤病毒(HPV)感染及亚型分布状况。方法以2018年10月至2020年7月中山博爱医院收治的2756例HPV阳性患者作为研究对象:依据宫颈疾病病理诊断结果将患者分为宫颈炎组(n=34)、单纯HPV感染组(n=702)、低级别鳞状上皮内病变(LSIL)组(n=1564)、高级别鳞状上皮内病变(HSIL)组(n=425)及宫颈癌组(n=31),分析各组的HPV亚型分布及感染状态。结果中山市HPV阳性患者的高危型HPV感染率为28.96%,以HPV16、18型为主,分别为18.98%、9.98%;感染类型以单一感染为主,占99.85%。其中,高危型HPV感染率由高到低依次为宫颈癌组、HSIL组、LSIL组、单纯HPV感染组、宫颈炎组,差异有统计学意义(P <0.05)。随着宫颈疾病程度的加深,HPV16型感染率明显升高,差异有统计学意义(P <0.05)。各组的HPV16型感染率比较,差异有统计学意义(P <0.05)。各组的感染类型差异比较,差异无统计学意义(P> 0.05)。结论 HPV16、18型为中山市宫颈鳞状上皮内病变妇女HPV亚型的常见高危亚型,以单一感染类型为主,双重或多重感染不增加疾病风险。更多还原

【Abstract】 Objective To explore the conditions of human papilloma virus(HPV) infection and subtype distribution in the patients with cervical squamous intraepithelial lesion in Zhongshan City. Methods A total of 2756 HPV positive patients admitted to and treated in Boai Hospital of Zhongshan City from October 2018 to July 2020 were taken as the subjects of research. According to the pathological diagnosis of cervical diseases, the patients were divided into the cervicitis group(n=34), the single HPV infection group(n=702), the low-grade squamous intraepithelial lesion(LSIL) group(n=1564), the high-grade squamous intraepithelial lesion(HSIL) group(n=425) and the cervical cancer group(n=31). The subtype distribution and infection status of HPV in each group were analyzed. Results The high-risk HPV infection rate of the HPV positive patients in Zhongshan City was 28.96%, with HPV16 and HPV18 being the main types, which occupied 18.98% and 9.98% respectively. The main type of infection was single infection, which accounted for 99.85%. In detail, the order of the five groups were the cervical cancer group, the HSIL group, the LSIL group, the single HPV infection group and the cervicitis group from high to low in terms of high-risk HPV infection rate, and the differences were statistically significant(P < 0.05). The infection rate of HPV16 increased significantly with the deterioration of cervical diseases, and the differences were statistically significant(P < 0.05). When the infection rate of HPV16 was compared among the five groups, the differences were statistically significant(P < 0.05). When infection types were compared among the five groups, the differences were statistically insignificant(P > 0.05). Conclusion HPV16 and HPV18 are the common highrisk subtypes of HPV subtypes in the women with cervical squamous intraepithelial lesions in Zhongshan City, with single infection being the main type, and double infection or multiple infection do not increase disease hazards.更多还原