【摘要】 目的探讨分化型甲状腺癌（DTC）患者¹³¹I治疗前停服左旋甲状腺激素（L-T₄）后血脂、血压与甲状腺功能的相关性。方法回顾性分析云南省肿瘤医院116例DTC患者停服L-T₄前后的甲状腺功能与血脂、血压的相关性。结果停药后甲减组三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、总胆固醇（CHOL）、载脂蛋白B（ApoB）及舒张压（DBP）均高于停药前正常组,甲减组载脂蛋白A/载脂蛋白B（ApoA/ApoB）低于正常组（P <0.05）。甲减组高血压患病率（42.2%）高于正常组（29.3%）（P=0.040）。甲减组与正常组促甲状腺素（TSH）水平与各血脂及血压指标间均无明显相关性（P> 0.05）。停药后甲减组患者分为TSH<50μIU/ml组和TSH≥50μIU/ml组,两组的血脂、血压水平及高血压患病率比较,差异均无统计学意义（P> 0.05）。结论 DTC患者¹³¹I治疗前停服L-T₄后发生甲状腺功能减退时血脂及血压均发生异常,甲状腺功能减退达一定程度后血脂及血压变化不大。更多还原

【Abstract】 Objective To investigate the correlations between blood lipid（BL）, blood pressure（BP） and thyroid function in the patients with differentiated thyroid carcinoma（DTC） after the withdrawal of L-T₄ and before ¹³¹I treatment. Methods The correlations between BL, BP and thyroid function before and after the withdrawal of L-T₄ from 116 patients with DTC in Yunnan Cancer Hospital were analyzed retrospectively. Results After drug withdrawal, the levels of triglyceride（TG）, low density lipoprotein cholesterol（LDL-C）, total cholesterol（CHOL）, apolipoprotein B（ApoB） and diastolic blood pressure（DBP） in the hypothyroidism group were all higher than those in the normal group before drug withdrawal, and the levels of the apolipoprotein A/apolipoprotein B（ApoA/ApoB） in the hypothyroidism group were lower than those in the normal group（P < 0.05）. The prevalence of hypertension in the hypothyroidism group（42.2%） was higher than that in the normal group（29.3%）（P=0.040）. There were no significant correlations between the TSH level and the indices of BL and BP in both the hypothyroidism group and the normal group（P > 0.05）. After drug withdrawal, the patients with hypothyroidism were divided into the TSH < 50 μIU/ml group and the TSH ≥ 50 μIU/ml group. The results showed that there were no statistically significant differences in the levels of BL and BP and the prevalence of hypertension between the two groups（P > 0.05）. Conclusion After the withdrawal of L-T₄ and before ¹³¹I treatment, DTC patients exhibit abnormal BL and BP when hypothyroidism occurs. No significant change in BL and BP after hypothyroidism reached a certain degree.更多还原