【摘要】 目的探讨颞叶癫痫发作间歇期脑电生理信号变化与抑郁症状的关系。方法回顾性分析2016～2018年于广东三九脑科医院手术治疗的26例颞叶癫痫患者,采用立体定向脑电图(SEEG)采集癫痫发作间歇期的脑电生理信号,采用HAMD-24评价抑郁症状,分析两者之间的相关性。结果 1.HAMD-24量表总分与颞中回前部SEEG波幅绝对平均值、波幅标准方差、全频段总功率、delta功率及theta功率相关系数显著(r=0.479,P=0.018;r=0.486,P=0.016;r=0.414,P=0.044;r=0.439,P=0.032;r=0.410,P=0.046)。2. HAMD-24量表睡眠因子与颞中回前部SEEG波幅绝对平均值、波幅标准方差、全频段总功率、alpha功率及delta功率相关系数显著(r=0.463,P=0.023;r=0.469,P=0.021;r=0.441,P=0.031;r=0.453,P=0.026;r=0.453,P=0.026)。3.不伴抑郁组与伴抑郁组在颞中回前部SEEG波幅绝对平均值与波幅标准方差两个特征值中存在显著差异(t=2.182,P=0.041;t=2.214,P=0.042)。结论颞叶癫痫发作间歇期颞叶外侧脑电功率值的变异性可能与抑郁及睡眠症状相关。更多还原

【Abstract】 Objective To explore the relationship between the changes of brain electrophysiological signals and depressive symptoms during the intermission of temporal lobe epilepsy. Methods 26 patients with temporal lobe epilepsy who underwent surgery in Guangdong Sanjiu brain hospital from 2016 to 2018 were retrospectively analyzed. The EEG signals of epileptogenic interval were collected by stereotactic electroencephalogram(SEEG),and the depression symptoms were evaluated by HAMD-24. Results 1. The total score of HAMD-24 was significantly correlated with absolute mean amplitude,standard deviation of amplitude,total power of whole frequency band,delta power and theta power of anterior middle temporal gyrus(r=0.479,P=0.018;r=0.486,P=0.016;r=0.414,P=0.044;r=0.439,P=0.032;r=0.410,P=0.046).2. The sleep factor of HAMD-24 was significantly correlated with absolute mean amplitude,amplitude standard deviation of amplitude,full band total power,alpha power and delta power of anterior middle temporal gyrus were(r=0.463,P=0.023;r=0.469,P=0.021;r=0.441,P=0.031;r=0.453,P=0.026;r=0.453,P=0.026);3. There were significant differences in the absolute mean and standard deviation of SEEG amplitude in the anterior part of the middle temporal gyrus between the group without depression and the group with depression(t=2.182,P=0.041;t=2.214,P=0.042). Conclusion The variability of lateral temporal lobe EEG power during the intermission of temporal lobe epilepsy may be related to depression and sleep symptoms.更多还原