【摘要】 子痫前期(PE)是一种多系统受累的妊娠并发症,与全球母亲和胎儿的死亡率和发病率有关。胎盘中螺旋动脉的异常重塑、胎盘缺陷、母胎界面的氧化应激、母体循环中的炎症和血管生成障碍是PE的主要原因。这些事件导致全身弥漫性内皮细胞功能障碍,这是PE的基本病理生理特征。微生物及其衍生物通过产生抗原和其他炎性因子可能触发感染和炎性反应。母亲在口腔、肠道、阴道、宫颈和子宫中的细菌群落以及胎盘和羊水微生物群可能与PE的发展有关。综述细菌及其衍生物在PE发展中的机制和致病作用,强调了一组母体微生物群的改变(菌群失调)对PE发病机制的影响。更多还原

【Abstract】 Pre-eclampsia(PE) is a multisystem pregnancy complication associated with maternal and fetal mortality and morbidity worldwide. Abnormal remodeling of spiral arteries in placenta, placental defects, oxidative stress at maternal-fetal interface,inflammation in maternal circulation and disturbance of angiogenesis are the main causes of PE. These events lead to systemic diffuse endothelial cell dysfunction, which is the basic pathophysiological feature of PE. Microorganisms and their derivatives may trigger infection and inflammatory responses by producing antigens and other inflammatory factors. The bacterial community in the mouth,intestines, vagina, cervix and uterus of the mother, as well as the microflora of placenta and amniotic fluid may be related to the development of PE. We reviewed the mechanism and pathogenicity of bacteria and their derivatives in the development of PE and emphasized the effect of a group of maternal microbiota changes(flora imbalance) on the pathogenesis of PE.更多还原