【摘要】 目的分析捐精志愿者筛查结果,探讨影响捐精志愿者筛查合格率的因素,为促进精子库建立规范有效的捐精志愿者筛查程序提供依据。方法回顾性分析2016年1月至2020年9月四川大学华西第二医院人类精子库6 349名捐精志愿者的筛查结果,对捐精志愿者的人群分布,捐精流程的完成情况及捐精志愿者的淘汰原因进行分析。结果 (1)6 349名捐精志愿者中,有学生1 793人(28.24%),社会人士4 556人(71.76%),学生人群的捐精志愿者筛查合格率(22.25%)明显高于社会人士(19.10%)(P<0.05),学生人群在筛查阶段退出捐精流程的比例(29.56%)明显低于其他社会人士(34.00%)(P<0.05)。(2)共有2 079名捐精志愿者(32.75%)在筛查阶段退出捐精,3 001名捐精志愿者(47.27%)因各种原因被淘汰,1 269名捐精志愿者(19.99%)筛查合格并进入正式捐精。(3)捐精志愿者主要的淘汰原因为精液质量没有达到国家卫生部门要求的捐精标准,共计2 406名(80.17%),其次为TORCH阳性,共162名(5.40%)、精液病原微生物检测阳性150名(5.00%),病史筛查/体格检查不合格、染色体异常及血常规异常占比较小。结论精子库在捐精志愿者宣传招募时应注重高校学生等重点人群的宣传,减少捐精志愿者的流失,提高捐精筛查合格率;精子库应当严格把控捐精志愿者的筛查标准,以确保供精冷冻精液标本的质量和安全性。更多还原

【Abstract】 Objective To analyze the screening results of sperm donors and to investigate the factors that affect the screening eligible rate of sperm donors, and provide a basis for human sperm bank to conduct a standardized and effective screening procedures for sperm donors.Methods The retrospetive research was based on the screening results of 6 349 sperm donors in human sperm bank of Sichuan from January 2016 to September 2020.The population distribution of sperm donors, the completion of the sperm donation process and the eliminated reasons of sperm donors were analyzed.Results(1) Among the 6 349 recruits, 1 793 were students(28.24%) and 4 556(71.76%) were other individuals, the screening eligible rate of students(22.25%) were significantly higher than that of other individuals(19.10%)(P<0.05),the proportion of students(29.56%) who quitted from sperm donation during the screening process was significantly lower than that of other individuals(34.00%)(P<0.05).(2) A total of 2 079 sperm donors(32.75%) who quitted from sperm donation during the screening process, 3 001 sperm donors(47.27%) were eliminated due to various reasons, and 1 269 sperm donors passed the screening process and became the formal sperm donors.(3) The main reason for the elimination of sperm donation volunteers was the semen quality did not meet the standard of sperm donation required by the national health department, with a total of 2 406(80.17%),followed by TORCH infections 162 cases(5.40%),and 150 cases(5.00%) semen pathogenic microorganisms infections, sperm donors failed on physical examinations/diseases history screening, chromosome or blood test which were accounted for relatively small proportions.Conclusion In order to reduce the loss of sperm donors and increase the screening eligible rate of sperm donors, human sperm bank should pay attention to the publicity of college students and other key populations during the recruitment of sperm donors.Human sperm bank should strictly control the screening standards of sperm donors to ensure the quality and safety of frozen semen samples.更多还原