【摘要】 目的通过多个数据库对蛋白激酶Cδ(PRKCD)的表达水平与肝细胞癌(HCC)的相关性进行分析,探讨PRKCD作为HCC新的诊断和治疗靶点的价值。方法通过生物信息学工具联合分析PRKCD基因在HCC中的预后价值及其调控机制。结果 HCC患者PRKCD表达水平明显高于癌旁和正常组织,差异均有统计学意义(P<0.05);疾病不同亚组分析结果表明,PRKCD表达水平升高与年龄、肥胖、疾病不同阶段等因素均相关(P<0.05);生存分析结果表明,PRKCD表达水平与预后呈明显负相关(P<0.05);功能网络分析显示,PRKCD可能与细胞分裂相关。结论 HCC患者体内PRKCD表达水平升高,且与预后不良密切相关,提示PRKCD有望成为HCC诊断和治疗的新靶点。更多还原

【Abstract】 Objective To explore the value of protein kinase C δ(PRKCD) as a new diagnostic and therapeutic target for hepatocellular carcinoma(HCC) by analyzing the correlation between the expression level of PRKCD and through multiple databases.Methods Bioinformatics tools was used to jointly analyze the prognostic value of PRKRD in hepatocellular carcinoma and its regulatory mechanism.Results The expression of PKRCD was significantly higher in hepatocellular carcinoma than that in precancerous, and normal tissues, and the differences were statistically significant(P<0.05).The analysis results of different subgroups of diseases indicated that the increase of expression of PRKCD was related to factors such as age, obesity and different stages of the disease(P<0.05).Survival analysis results showed that its expression level was significantly negatively correlated with prognosis.Functional network analysis showed that PRKCD might be related to cell division.Conclusion PRKCD levels in patients with hepatocellular carcinoma are elevated and are closely related to poor prognosis.It is suggested that PRKCD may become a new target for diagnosis and treatment of hepatocellular carcinoma.更多还原