【摘要】 目的探讨脑膜病理检查在疑似脑膜转移癌患者中的价值。方法回顾性分析该院2019年3月—2020年07月收治的20例初诊为脑膜转移癌的患者,在为其行脑室腹腔分流(VP)、Ommaya囊植入和脑室外引流术时取脑膜组织行病理检查。结果该组20例患者中共有15例患者的脑膜病理活检为异常,阳性率为75%,其中13例为脑膜转移瘤,另2例分别为胶质母细胞瘤和结核性脑膜炎。所有患者均无取标本带来的相关并发症。结论脑膜病理检查能提高脑膜转移癌的确诊率,为实施精准放疗和个性化化疗提供依据,是一种简单、安全并且能够确诊脑膜转移癌的重要方法。[国际神经病学神经外科学杂志, 2021, 48(2):154-158]更多还原

【Abstract】 Objective To investigate the value of meningeal pathological examination in patients suspected of leptomeningeal metastasis.Methods A retrospective analysis was performed for 20 patients who were admitted to our hospital from March 2019 to July 2020 and were initially diagnosed with leptomeningeal metastasis,and meningeal tissue was collected for pathological examination during ventriculoperitoneal shunt,Ommaya capsule implantation,and external ventricular drainage.Results Among the 20 patients,15 had abnormal results of meningeal biopsy,resulting in a positive rate of75%,among whom 13 had leptomeningeal metastasis and 2 had glioblastoma and tuberculous meningitis,respectively.No complications associated with specimen collection were found in patients.Conclusion Meningeal pathological examination can improve the confirmed diagnosis rate of leptomeningeal metastasis and provide a basis for implementing precision radiotherapy and personalized chemotherapy.It is a simple,safe,and important method to make a confirmed diagnosis of leptomeningeal metastasis.[Journal of International Neurology and Neurosurgery,2021,48(2):154-158]更多还原