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子宫内膜干/祖细胞与子宫内膜异位症发病机制的研究进展
Endometrial Stem/Progenitor Cells and the Pathogenesis of Endometriosis
【摘要】 子宫内膜干/祖细胞的发现为子宫内膜异位症发病机制的研究提供了新的思路。子宫内膜干/祖细胞根据其表面标志物及在人体中功能、位置的不同分为子宫内膜上皮祖细胞、子宫内膜间充质干细胞、侧群细胞、巢细胞等。子宫内膜干/祖细胞的发现完善了Sampson的经血逆流学说,为青春期子宫内膜异位症的发病提供了新的合理的解释。对子宫内膜干/祖细胞的深入研究将为子宫内膜异位症的诊断和治疗提供新的可能。
【Abstract】 The endometrial stem/progenitor cells are new targets for the study of the pathogenesis of endometriosis. According to their surface markers and functions in human body, endometrial stem/progenitor cells can be divided into four subgroups: endometrial epithelial progenitor cells, endometrial mesenchymal stem cells,side population cells, niche cells. The discovery of endometrial stem/progenitor cells has improved the Sampson′s theory of retrograde menstruation, and provided a new and reasonable explanation for the pathogenesis of adolescent endometriosis. The further study of endometrial stem/progenitor cells will provide a new possibility for the diagnosis and treatment of endometriosis.
【Key words】 Endometriosis; Endometrium; Stem cells; Mesenchymal stromal cells;
- 【文献出处】 国际生殖健康/计划生育杂志 ,Journal of International Reproductive Health/Family Planning , 编辑部邮箱 ,2021年04期
- 【分类号】R711.71
- 【被引频次】5
- 【下载频次】416