【摘要】 目的:观察结核丸联合化疗治疗反复性、难治性结核病的临床疗效。方法:选择202例确诊的复治涂阳肺结核患者,随机分为观察组和对照组,每组101例。对照组给予单纯抗结核药物治疗,观察组内服抗结核药物联合中药结核丸治疗。观察两组临床疗效、痰检结果、痰涂片转阴率、症状变化及肝功能指标。结果:观察组临床有效率[99.01%(100/101)]优于对照组[92.08%(93/101)](P<0.05)。观察组治疗第8、24周痰检转阴率分别为96.04%(97/101)及100%(101/101);对照组治疗第8、24周痰检转阴率均为99.01%(100/101),两组比较差异无统计学意义(P>0.05)。治疗第4、8、24周后,ALT及AST水平,观察组均较对照组同期降低明显,差异有统计学意义(P<0.05)。结论:结核丸联合化疗治疗反复性、难治性肺结核,可提高临床疗效、痰检转阴率,改善临床症状,且可缓解肝功能损伤。更多还原

【Abstract】 Objective: To observe clinical effects of tuberculosis pills and chemotherapy in the treatment of recurrent refractory tuberculosis. Methods: All 202 patients who were confirmed and retreatment of smear positive pulmonary tuberculosis were selected and randomized into the observation group and the control group, 101 cases in each group. The control group accepted only antituberculosis drugs, and the observation group oral antituberculosis drugs and tuberculosis pills. To observe clinical effects, the results of sputum examination, negative conversion rate of sputum smear, the changes of the symptoms and the indexes of liver function between both groups. Results: Clinical effective rate of the observation group was 99.01%(100/101), superior to 92.08%(93/101) of the control group(P<0.05); the results of sputum examination, negative conversion rates of the observation group at the eighth and 24 th week of treatment were 96.04%(97/101) and 100%(101/101) respectively, while the rates of the control group at the eighth and 24 th week of treatment were 99.01%(100/101) and 99.01%(100/101),and the difference had no statistical meaning between both groups(P>0.05); after four, eight and 24 weeks of treatment, the levels of ALT of the observation group lowered compared with these of the control group, and the difference had statistical meaning(P<0.05); after eight and 24 weeks of treatment, the levels of AST of the observation group reduced compared with the control group, and the difference showed statistical meaning(P<0.05).Conclusion: Tuberculosis pills and chemotherapy in the treatment of recurrent refractory tuberculosis could raise clinical effects and negative conversion rates of sputum examination, improve clinical symptoms and relieve liver function damage.更多还原