【摘要】 目的观察不同剂量来曲唑联合促性腺激素治疗克罗米芬抵抗多囊卵巢综合征(PCOS)的效果。方法135例克罗米芬抵抗PCOS患者随机分为A、B、C组,分别给予来曲唑2.5 mg/d、5.0 mg/d、20 mg顿服联合促性腺激素治疗。比较3组疗效、性激素水平、促排卵效果和不良反应。结果 B、C组疗效、血清雄激素(LH、E2、FSH)水平、优势卵泡数目、妊娠率高于A组,而卵泡成熟时间、成熟卵泡直径及促性腺激素用量少于A组(P<0.01或0.05)。结论 20 mg来曲唑顿服联合促性腺激素治疗克罗米芬抵抗PCOS促排卵效果较好,可提高妊娠率。更多还原

【Abstract】 Objective To observe the clinical efficacy of combined gonadotropin and different doses of letrozole in clomiphene-resistant polycystic ovary syndrome(PCOS). Methods A total of 135 patients with clomiphene-resistant PCOS were randomly treated with 2.5 mg/d letrozole plus gonadotropin(group A), 5.0 mg/d letrozole plus gonadotropin(group B) or single dose of 20 mg letrozole plus gonadotropin(group C). Clinical efficacy, serum levels of sex hormones,ovulation induction and adverse reactions were compared among 3 groups. Results Compared with group A, clinical efficacy, serum levels of sex hormones(LH、E2、FSH), dominant follicles, and pregnancy rate were higher, while follicular maturation time, mature follicle diameter, and gonadotropin usage were lower in groups B and C( P <0.01 or 0.05).Conclusion Single dose of 20 mg letrozole plus gonadotropin can improve ovulation induction and pregnancy rate in patients with clomiphene-resistant PCOS.更多还原