【摘要】 炎症性肠病(IBD)是一种慢性的,易复发的胃肠道炎性疾病。克罗恩氏病(CD)和溃疡性结肠炎(UC)可能是由于环境和遗传易感宿主中肠道菌群之间的平衡受损,从而导致不适当的免疫激活和促炎性细胞因子的过度生产。IL-6是机体发生炎症反应时的重要调节因子,与IBD以及其他慢性炎症性疾病有关。IL-6诱导的信号转导主要出现在相对较少的IL-6响应细胞中,而在炎症的慢性期,它能够通过称为反转录的过程激活体内几乎所有细胞信号。这篇综述中我们研究讨论了IL-6对IBD的作用。更多还原

【Abstract】 Inflammatory bowel disease(IBD) is a chronic, recurrent gastrointestinal inflammatory disease. Crohn’s disease(CD) and ulcerative colitis(UC) may be due to impaired balance between the environmental and genetically susceptible host gut microbiota, resulting in inappropriate immune activation and over production of pro-inflammatory cytokines. IL-6 is an important regulator of inflammatory response, which is related to IBD and other chronic inflammatory diseases. The signal transduction induced by IL-6 mainly occurs in relatively few IL-6 responsive cells. In the chronic phase of inflammation, it can activate almost all cell signals in the body through a process called reverse transcription. In this review, we discuss the effect of IL-6 on IBD.更多还原