【摘要】 阐明精神分裂症的病因和发病机制是医学面临的重要挑战之一,同时也是法医司法鉴定的重要内容之一。精神分裂症的多巴胺假说认为多巴胺能系统的失调是精神分裂症的病因,DRD3基因在脑中的区域性高表达以及其与众多精神疾病的阳性关联提示其在精神分裂症中的潜在重要性。本文综述了DRD3基因在精神分裂症的群体遗传学、动物模型和在人源细胞表达情况的研究现状,认为DRD3基因参与精神分裂症的发病机制并且在未来可能作为一个重要的遗传学指标而应用到法医精神病学的鉴定当中。更多还原

【Abstract】 To clarify the etiology and pathogenesis of schizophrenia is one of the most important challenges faced by medicine, and it is also one of the important contents of judicial authentication. The dopamine hypothesis of schizophrenia holds that disorders of the dopaminergic system are the cause of schizophrenia. The regional high expression of DRD3 gene in brain and its positive association with many psychiatric disorders suggest its potential importance in schizophrenia. This paper reviews the research status of DRD3 gene in population genetics, animal models and human cell expression in schizophrenia. It is believed that DRD3 gene is involved in the pathogenesis of schizophrenia and may be used as an important genetic indicator in judicial identification of psychiatric disorders in the future.更多还原