【摘要】 目的:分析脑电图(EEG)结果正常的特发性全面性癫痫(IGE)患儿扩散峰度成像(DKI)的各向特征值。方法:将头皮EEG结果正常的9例IGE患儿与18例年龄、性别匹配的正常对照(NC)组儿童的头部DKI影像,通过基于体素分析方法估计,DKI参数各向异性分数(FA)、平均扩散吸系数(MD,)及平均峰度值(MK),MD包括MD⊥和MD//,MK包括MK⊥和MK//,比较病例组与NC组间DKI参数的差异。结果:在病例与NC组比较中,病例组FA减低区域为体素簇391左侧半球额叶白质、114下额叶皮层灰质、100脑回下区域等区域。病例组MD增高区域为体素簇362左侧大脑半球颞叶白质及240颞中回。病例组MK//异常区域为体素簇66的左侧大脑半球叶下区域。结论:DKI各特征值可检出EEG正常IGE患儿脑白质、灰质异常,可为临床抗癫痫药物治疗及随访提供影像信息支持。更多还原

【Abstract】 Objective:To evaluate Electroencephalogram(EEG)-negative idiopathic generalized epilepsy(IGE) in children using diffusion kurtosis imaging(DKI) with the indices of fractional anisotropy(FA),mean diffusion(MD) and mean kurtosis(MK).Methods:DKI images were obtained from nine IGE children without interictal epileptiform discharges(IED) recorded from EEG,18 age-and sex-matched children were enrolled as the normal control(NC) group and compared with the IGE group.FA,MD(MD⊥、MD//) and MK(MK⊥、MK//) were estimated through voxel-based analysis.Statistics was compared among the IGE group and the NC group.Results:The reduction of FA were found in the left cerebrum of white matter(WM)(391),brodmann area 47(114) and sub-gyral area(100).The increase of MD were found in the left cerebrum, temporal lobe of WM(362) and middle temporal gyrus(240).The significant differences of MK//were in the sub-lobar area of left cerebrum(66).Conclusion: The indices of DKI could detect WM and GM abnormalities in EEG-negative IGE children, and can provide imaging information support in treatment with antiepileptic drugs and in follow-up study.更多还原