【摘要】 聚集诱导发光(Aggregation-induced emission, AIE)探针由于其极高的灵敏度和极佳的光稳定性在癌症诊断和治疗等方面具有不可估量的应用前景。线粒体作为所有细胞共有的重要细胞器,在癌细胞和正常细胞中显示出明显的性质区别,因此可作为线粒体靶向AIE探针区分癌细胞与正常细胞的靶标。本文介绍了线粒体靶向AIE探针的设计方法、成像机理以及它们对癌细胞与正常细胞、循环肿瘤细胞与白细胞以及癌细胞和相关细菌与正常细胞的区别成像。这些荧光探针在癌症诊断、手术导航、癌症治疗的效果评估和后续复发监测以及细胞污染评估等方面具有广阔的应用前景。通过本文的介绍,能够让更多读者了解AIE探针在癌细胞识别方面的显著优势,激发开发性能更为丰富的探针材料和开展更为深入的研究,从而促进生物医学领域的快速发展,造福人类。更多还原

【Abstract】 Aggregation-induced emission(AIE) probes have shown great potential in cancer diagnosis and therapy due to their excellent sensitivity and photo-stability. Mitochondria, which is regarded as one of the most important organelles in cells, has obvious difference between cancer cells and normal cells. Thus, it is reliable to utilize mitochondria-targeted AIE probes to distinguish cancer from normal cells. In this review, we exhibit the design principle and imaging mechanism of AIE probes for mitochondria target, and their distinguishing imaging between cancer cells and normal cells, circulating tumor cells and leukocyte, and dual identification imaging of cancer cells and related bacteria. The probes show remarkable advantages in cancer diagnosis, surgical navigation, cancer treatment assessment and recurrence monitoring, and cell pollution evaluation. We hope, this review will motivate to develop more AIE probes with rich properties and conduct deeper researches to promote the rapid development of biomedical field and maintain human health.更多还原