【摘要】 目的探讨饮酒与血小板稳态之间的关系。方法 2018年5月—7月在常州天宁区以社区为单位测定了4 739例成人血小板参数,包括血小板计数、大血小板百分比、平均血小板体积、血小板压积和血小板分布宽度,应用标准化问卷评估了所有研究对象的饮酒状况。应用线性回归模型、分位数回归模型和logistic回归模型分析饮酒与血小板稳态之间的关系。结果单因素logistic回归分析结果显示,乙醇使用障碍筛查量表评分增加与平均血小板体积异常风险增加有关(P=0.01)。除大血小板百分比外,其余血小板稳态异常指标均与乙醇使用障碍筛查量表等级相关(P<0.05)。经过多因素调整后,血小板压积异常与血小板分布宽度高水平风险随乙醇使用障碍筛查量表评分增加而增加;乙醇使用障碍筛查量表等级仅与平均血小板体积异常有关。结论饮酒与血小板稳态之间存在相关性,而且饮酒可能通过影响血小板稳态进而对心血管产生不良影响。更多还原

【Abstract】 Objective Explore the relationship between drinking and platelet homeostasis. Methods From May to July 2018 in Tianning District, Changzhou, a total of 4,739 adult platelet parameters were measured on a community basis, including platelet count, large platelet percentage, average platelet volume, platelet compaction, and platelet distribution width, and standardized questionnaires were used to evaluate the drinking status of all subjects in the study. Linear regression model, quantile regression model and logistic regression model were used to analyze the relationship between drinking and platelet homeostasis. Results Univariate logistic regression analysis showed that the increase in the score of the Ethanol Use Disorder Screening Scale was significantly associated with an increase in the risk of abnormal average platelet volume(P = 0.01). Except for the percentage of large platelets, the other abnormal indexes of platelet homeostasis were all related to the grade of the alcohol use disorder screening scale(P < 0.05). After multi-factor adjustment, the risk of abnormal platelet volume and high platelet distribution width increased with the increase of the ethanol use disorder screening scale; the level of the ethanol use disorder screening scale was only related to abnormal average platelet volume. Conclusion There is a correlation between drinking and platelet homeostasis, and drinking may have adverse effects on cardiovascular by affecting platelet homeostasis.更多还原