【摘要】 猪流行性腹泻是由猪流行性腹泻病毒(PEDV)引起的一种高度传染性疾病,给全球养猪业造成了严重的经济损失。PEDV的S蛋白同时具有受体结合和膜融合功能。S蛋白与宿主细胞受体之间相互作用,细胞蛋白酶对S蛋白的水解激活,病毒膜融合的方式对PEDV的组织嗜性、宿主范围,发病机制起到关键作用。因此,从PEDV的组织和细胞嗜性、细胞受体、入胞方式、细胞蛋白酶等方面着手,研究病毒的入胞机制对病毒感染的预防和治疗具有重要意义,也为后续的基础研究及PEDV的防控提供理论支持。更多还原

【Abstract】 Porcine epidemic diarrhea is a highly contagious disease caused by porcine epidemic diarrhea virus(PEDV),which has caused serious economic losses to the global pig industry.The spike protein of PEDV has both receptor binding and fusion functions.The interaction between S protein and host cell receptors, the hydrolysis and activation of S protein by cellular proteases, and the way of viral membrane fusion play key roles in the tissue tropism, host range, and pathogenesis of PEDV.Therefore, it is of great significance to study the mechanism of virus entry from the aspects of tissue and cell tropism, cellular receptors, entry pathway, cellular proteases, etc.,for the prevention and treatment of viral infections, and it is also important for subsequent basic research of PEDV and providing theoretical support for prevention and control.更多还原