【摘要】 晚期声带麻痹喉肌功能损伤是咽喉外科亟待解决的难题。环状RNA(circRNA)是通过非经典剪接方式形成的一种内源性环形非编码RNA,它可能通过miRNA海绵、可变剪接调节因子等方式在多种疾病的发生、发展中起重要作用,是潜在的疾病早期诊断生物标志物或干预治疗的新靶点。随着研究的不断深入,circRNA与神经、肌肉功能及相关疾病的关系也受到学者们的广泛关注。本文围绕circRNA的分子特征、形成机制、作用模式及其与神经、肌肉功能、相关疾病的研究进展进行综述,以期为晚期声带麻痹的治疗提供新的思路。更多还原

【Abstract】 Laryngeal muscle function impairment caused by advanced vocal fold paralysis is an urgent problem to be solved in throat surgery. Circular RNA(circ RNA) is a kind of endogenous loop non-coding RNA formed by non-classical splicing. It may play an important role in the development and progression of various diseases through micro RNA(mi RNA) sponge, alternative splicing regulators and so on. It is a potential biomarker for early diagnosis of diseases or a new target for intervention therapy. With the deepening of research, the relationship between circ RNA and nerve, muscle functions and related diseases has also been widely concerned by scholars. This review focuses on circ RNA’s molecular characteristics, formation mechanism, mode of action, and its research progress in nerve, muscle functions and related diseases, so as to provide new ways for the treatment of advanced vocal fold paralysis.更多还原