【摘要】 目的探究小剂量多巴胺联合磷酸肌酸钠治疗小儿肺炎并心力衰竭的临床效果。方法选取2018年1月至2020年1月本院收治的68例小儿肺炎伴有心力衰竭患者作为研究对象,按数字奇偶法分为联合组与单一组,每组34例。单一组采用磷酸肌酸钠药物治疗,联合组在单一组基础上联合小剂量多巴胺治疗。比较两组临床疗效、血清学指标、心功能指标及不良反应发生率。结果联合组治疗总有效率为94.12%,明显高于单一组的58.82%,差异有统计学意义(P<0.05)。治疗前,两组D-D、IGF-1、PCT及cTnI指标比较差异无统计学意义;治疗后,联合组D-D、IGF-1、PCT及cTnI均明显低于单一组,差异有统计学意义(P<0.05)。治疗前,两组LVESd、LVEF、QTd、LVEDd比较差异无统计学意义;治疗后,联合组LVEDd、LVESd、QTd均明显低于单一组,LVEF明显高于单一组(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论小剂量多巴胺联合磷酸肌酸钠药物治疗小儿肺炎并心力衰竭效果显著,可显著改善患儿血清学指标、心功能指标,不增加不良反应,具有较高安全性,值得临床推广应用。更多还原

【Abstract】 Objective To explore the clinical effect of low-dose dopamine combined with creatine phosphate sodium on children with pneumonia and heart failure. Methods 68 cases pediatric pneumonia patients with heart failure admitted to our hospital from January 2018 to January 2020 were selected as the research subjects, and divided into combined group and single group according to the numerical odd-even method, with 34 cases in each group. The single group was treated with creatine phosphate sodium medication, and the combined group was treated with low-dose dopamine on the basis of the single group. The clinical efficacy, serological indexes, cardiac function indexes and incidence of adverse reactions were compared between the two groups. Results The total effective rate in combined group was 94.12%, which was significantly higher than 58.82% in single group(P<0.05). Before treatment, there were no significant difference in D-D, IGF-1, PCT and c TnI between the two groups. After treatment,D-D, IGF-1, PCT and cTnI in the combined group were significantly lower than those in the single group, the differences was statistically significant(P<0.05). Before treatment, there was no significant difference in LVESd, LVEF, QTd and LVEDd between the two groups. After treatment,LVEDd, LVESd and QTd in combined group were significantly lower than those in single group, while LVEF was significantly higher than that in single group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion Low-dose dopamine combined with creatine phosphate in the treatment of children with pneumonia and heart failure has significant effect, which can significantly improve the serological indicators and cardiac function indicators, without increasing adverse reactions, with high safety, it is worthy of clinical application.更多还原