【摘要】 通过静电纺丝技术一步制备出表面带有纳米沟槽结构的微米级左旋聚乳酸(PLLA)纤维支架,同时具备纳米和微米结构优势。对支架的形态、力学性能、生物相容性和细胞渗透情况进行表征。结果表明:当PLLA纺丝液浓度提高时,纤维直径随之增大,但不会影响纤维表面的纳米沟槽结构;表面的纳米沟槽结构能增大支架的比表面积,促进细胞的黏附和迁移;用质量浓度为230 g/L的PLLA纺丝液制得的支架,其纤维的平均直径达到3.00μm以上,支架的平均孔径扩大到12.00μm以上,能有效地促进细胞的增殖及三维浸润。更多还原

【Abstract】 The poly(L-lactic acid)(PLLA) fiber scaffold with nano groove structure was prepared by electrospinning technology in one step, and this scaffold had the advantages of both nano and micro structure. The scaffold was characterized in terms of morphology, mechanical properties, biocompatibility and cellular infiltration. The test results showed that, the fiber diameter increased as the increase of the concentration of spinning solution, but it didn’t affect the nano groove on the fiber surface. The nano groove on the fiber surface could increase the specific surface area of scaffolds and promote the adhesion and migration of cells. The average fiber diameter of the scaffold prepared with 230 g/L PLLA spinning solution was more than 3.00 μm and the average pore size of the scaffold was expanded to over 12.00 μm, which could effectively promote cell proliferation and three-dimensional infiltration.更多还原