【摘要】 以健康雄性SD大鼠为试验对象,信阳毛尖茶水提物为受试物,气管滴注PM_2.5（Fine particulate matter）悬浮液建立慢性肺损伤模型,研究信阳毛尖茶水提物对滴注PM_2.5大鼠体重增长率、肺组织形态学、肺组织病理学的影响,并对大鼠血清和支气管肺泡灌洗液（BALF）的生化指标进行测定。结果表明,信阳毛尖茶水提物一定程度上具有拮抗PM_2.5导致的大鼠体重增长率降低以及肺部损伤等作用;此外,信阳毛尖茶水提物可有效阻止大鼠血清和BALF中白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、免疫球蛋白G（IgG）含量和乳酸脱氢酶（LDH）活性上升,以及超氧化物歧化酶（SOD）活性的下降,其效果与浓度呈良好的剂量关系。更多还原

【Abstract】 In this study, the healthy male sprague-dawley（SD） rats were taken as experimental subjects, and the water extracts of Xinyang Maojian tea were used as test substances, while intratracheal instillation of PM_2.5 suspension was established as chronic pulmonary injury model. Rats serum and biochemical indexes of bronchoalveolar lavage fluid（BALF） were tested. The results show that the tea extracts had antagonism effects on the reduce of rats growth rate and the lung injury caused by PM_2.5. Furthermore, the tea water extracts could effectively lower the increase of IL-1β, IL-6, TNF-α, IgG and the activity of LDH, and keep the activity of SOD in rats serum and BALF, showing a dose-dependent effects.更多还原