【摘要】 恶性肿瘤是导致高致死率的严重疾病。肿瘤免疫基础研究和有效抗肿瘤治疗的发展均依赖于实验系统,实验室小鼠常被用作生物模型来验证假设、探究人类疾病的机制和治疗相关疾病。在该系统中可以研究恶性细胞与免疫细胞之间的关系。恶性肿瘤的各种小鼠模型奠定了肿瘤免疫学的基础,指导了免疫监视、免疫平衡和免疫逃逸理论的形成,故构建动物模型在研究中起到至关重要的作用。本文就近年来有关肿瘤免疫的小鼠模型的发展及意义进行综述。更多还原

【Abstract】 Malignant tumor is a serious disease that causes a high fatality rate.Both basic research on tumor immunity and the development of effective anti-tumor therapies rely on the experimental systems.Laboratory mice are often used as the biological models to verify the hypotheses,explore the mechanisms of human diseases,and treat the related diseases.In this system,the relationship between the malignant cells and immune cells can be studied.Various mouse models of malignant tumors have laid the foundation for tumor immunology and guide the formation of immune surveillance,immune balance and immune escape theory,so establishing the animal models plays a vital role in research.This article reviews the development and significance of mouse models of tumor immunity in recent years.更多还原