【摘要】 设计、合成可能具有抗血小板聚集活性的查尔酮类化合物,为抗血小板聚集候选药物的开发提供参考。以（E）-查耳酮为模型化合物,依据药物化学中的分子片段理论,设计含有羟基的查尔酮类化合物。以取代苯甲醛或川芎嗪醛、丹皮酚或对羟基苯乙酮为起始原料,通过氧化反应、酯化反应、水解反应、羟醛缩合反应等步骤对设计的化合物进行合成。采用¹H NMR、¹³C NMR、MS技术手段对合成的化合物结构进行表征。实验设计、合成了9个查尔酮类化合物,丰富了该类化合物的结构库,为抗血小板聚集药物开发提供参考。更多还原

【Abstract】 This paper is to design and synthesize chalcone compounds with anti-platelet aggregation activity. The chalcone compounds provide a reference for the development of candidate drugs for anti platelet aggregation. According to the molecular fragment theory in pharmaceutical chemistryusing, chalcone compounds containing hydroxyl groups were designed based on（E）-chalcone as the model compound. Designed compounds were synthesized by oxidation reaction, esterification reaction, hydrolysis reaction and aldol condensation reaction. Their starting materials were substituted benzaldehyde or Ligustrazine aldehyde, paeonol or p-hydroxyacetophenone. The structures of the synthesized compounds were characterized by ¹H NMR, ¹³C NMR and MS. Nine chalcone compounds were designed and synthesized, which enriched the structural library of chalcone compounds and provided a reference for the development of antiplatelet aggregation drugs.更多还原