【摘要】 目的:筛选出抗氧化功能最佳的益气聪明汤配伍。方法:采用正交设计法对益气聪明汤进行加减方配伍,对给药后D-半乳糖氧化损伤小鼠肝脏中MDA含量、SOD活性和GSH-Px活性进行测定,研究益气聪明汤加减法的抗氧化功能。结果:丹参、葛根、短梗五加、北沙参、人参、黄芪、甘草和白芍的益气聪明汤配伍能明显增加D-半乳糖氧化损伤小鼠肝脏中SOD和GSH-Px活性,降低肝脏中MDA含量。结论:抗氧化作用最佳的益气聪明汤配伍为丹参10g、葛根10g、短梗五加10g、北沙参10g、人参16g、黄芪16g、甘草16g和白芍3g。更多还原

【Abstract】 Objective: Compatibility of Yiqi Congming Decoction with the best anti-oxidative effect was screened. Methods: Compatibility of Yiqi Congming Decoction is modified by using orthogonal design method. MDA content, SOD activity, and GSH-Px activity in liver of oxidative damage mouse by D-galactose after administration are determined, and the antioxidant function of Yiqi Congming Decoction is studied. Results: Compatibility of Yiqi Congming Decoction including Salvia Miltrorrhiza, Radix Puerariae, Acanthopanax Sessiliflorus, Radix Glehniae, Ginseng, Milkvetch Root, Radix Glycyrrhizae and White Paeony Root could increase SOD and GSH-Px activities in the liver of oxidative damage mice by D-galactose, and decrease MDA content in its liver. Conclusion: The anti-oxidative effect of compatibility of Yiqi Congming Decoction including Salvia Miltrorrhiza 10 g, Radix Puerariae 10 g, Acanthopanax Sessiliflorus 10 g, Radix Glehniae 10 g, Ginseng 16 g, Milkvetch Root 16 g, Radix Glycyrrhizae 16 g and White Paeony Root 3 g was best.更多还原