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振幅整合脑电图在晚期早产儿PIVH中的应用研究

Clinical application value of amplitude-integrated electroencephalography in late preterm infants with periventricular-intraventricular hemorrhage

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【作者】 李丹丹韩旻温晓红

【Author】 LI Dan-dan;HAN Min;WEN Xiao-hong;Department of Pediatrics,The Third People′s Hospital Affiliated to Bengbu Medical College;Department of Pediatrics,The First People′s Hospital of Hefei;

【通讯作者】 韩旻;

【机构】 蚌埠医学院附属蚌埠市第三人民医院儿科安徽省合肥市第一人民医院儿科

【摘要】 目的:研究振幅整合脑电图(aEEG)在晚期早产儿脑室周-脑室内出血(PIVH)中的改变及其早期诊断PIVH的临床价值。方法:选取入住NICU、出生胎龄为34~36+6周的晚期早产儿82例,于生后72 h内行aEEG检查,生后10 d内行颅脑彩超检查。根据胎龄不同分为3组,分别是34周组(34~34+6周)、35周组(35~35+6周)和36周组(36~36+6周)。再根据彩超检查结果,在每个胎龄组的基础上再分为PIVH组和无PIVH组。结果:3个胎龄PIVH组患儿aEEG在总分评分、睡眠觉醒周期评分、35周和36周胎龄组带宽的评分均低于无PIVH组患儿(P<0.01)。约登指数最大时,34周组的总分最佳截断值为8.5,灵敏度73.31%,特异性81.80%;35周组的总分最佳截断值为9.5,灵敏度71.43%,特异性92.32%;36周组的总分最佳截断值为10.5,灵敏度84.62%,特异性87.51%。结论:晚期早产儿PIVH组患儿aEEG在总分、睡眠觉醒周期及35周和36周胎龄组带宽的评分低于无PIVH组患儿。各胎龄在取最佳截断值时,aEEG对诊断PIVH有较高的灵敏度及特异性。

【Abstract】 Objective:To investigate the changes of amplitude-integrated electroencephalography(aEEG) in late preterm infants with periventricular-intraventricular hemorrhage(PIVH),and its clinical value in early diagnosis of PIVH.Methods:A total of 82 late preterm infants with gestational age ranging from 34-36+6 weeks were selected.The aEEG and craniocerebral ultrasound examination in the cases were performed within 72 hours and 10 d days after birth, respectively.According to the different gestational ages, the patients were divided into the 34-week group(34-34+6 weeks),35-week group(35-35+6 weeks) and 36-week group(36-36+6 weeks).According to the results of craniocerebral ultrasonography, each gestational age group was subdivided into the PIVH group and non-PIVH group.Results:Among three gestational ages groups, the total score, sleep wake cycle score and bandwidth scores of 35-week and 36-week patients of aEEG in PIVH group were lower than those in non-PIVH group(P<0.01).When the Youden index was the largest, the optimal cutoff value of total score, sensitivity and specificity in 34-week, 35-week and 36-week groups were(8.5,73.31% and 81.80%),(9.5,71.43% and 92.32%) and(10.5,84.62% and 87.51%),respectively.Conclusions:The total score, sleep wake cycle and bandwidth scores in 35-and 36-week patients of aEEG in PIVH group are lower than those in non-PIVH group.The aEEG has high sensitivity and specificity for PIVH diagnosis when the optimal cutoff value is selected for each gestational age.

【基金】 安徽省科技攻关计划项目(1604a0802093)
  • 【文献出处】 蚌埠医学院学报 ,Journal of Bengbu Medical College , 编辑部邮箱 ,2021年03期
  • 【分类号】R722.6
  • 【下载频次】23
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