【摘要】 目的:研究振幅整合脑电图（aEEG）在晚期早产儿脑室周-脑室内出血（PIVH）中的改变及其早期诊断PIVH的临床价值。方法:选取入住NICU、出生胎龄为34～36⁺⁶周的晚期早产儿82例,于生后72 h内行aEEG检查,生后10 d内行颅脑彩超检查。根据胎龄不同分为3组,分别是34周组(34～34⁺⁶周)、35周组(35～35⁺⁶周)和36周组(36～36⁺⁶周)。再根据彩超检查结果,在每个胎龄组的基础上再分为PIVH组和无PIVH组。结果:3个胎龄PIVH组患儿aEEG在总分评分、睡眠觉醒周期评分、35周和36周胎龄组带宽的评分均低于无PIVH组患儿（P<0.01）。约登指数最大时,34周组的总分最佳截断值为8.5,灵敏度73.31%,特异性81.80%;35周组的总分最佳截断值为9.5,灵敏度71.43%,特异性92.32%;36周组的总分最佳截断值为10.5,灵敏度84.62%,特异性87.51%。结论:晚期早产儿PIVH组患儿aEEG在总分、睡眠觉醒周期及35周和36周胎龄组带宽的评分低于无PIVH组患儿。各胎龄在取最佳截断值时,aEEG对诊断PIVH有较高的灵敏度及特异性。更多还原

【Abstract】 Objective:To investigate the changes of amplitude-integrated electroencephalography（aEEG） in late preterm infants with periventricular-intraventricular hemorrhage（PIVH）,and its clinical value in early diagnosis of PIVH.Methods:A total of 82 late preterm infants with gestational age ranging from 34-36⁺⁶ weeks were selected.The aEEG and craniocerebral ultrasound examination in the cases were performed within 72 hours and 10 d days after birth, respectively.According to the different gestational ages, the patients were divided into the 34-week group(34-34⁺⁶ weeks),35-week group(35-35⁺⁶ weeks) and 36-week group(36-36⁺⁶ weeks).According to the results of craniocerebral ultrasonography, each gestational age group was subdivided into the PIVH group and non-PIVH group.Results:Among three gestational ages groups, the total score, sleep wake cycle score and bandwidth scores of 35-week and 36-week patients of aEEG in PIVH group were lower than those in non-PIVH group（P<0.01）.When the Youden index was the largest, the optimal cutoff value of total score, sensitivity and specificity in 34-week, 35-week and 36-week groups were（8.5,73.31% and 81.80%）,（9.5,71.43% and 92.32%） and（10.5,84.62% and 87.51%）,respectively.Conclusions:The total score, sleep wake cycle and bandwidth scores in 35-and 36-week patients of aEEG in PIVH group are lower than those in non-PIVH group.The aEEG has high sensitivity and specificity for PIVH diagnosis when the optimal cutoff value is selected for each gestational age.更多还原