【摘要】 目的:设计、合成四氢异喹啉酰胺类化合物,为开发更为安全、有效的抗血小板聚集候选药物提供参考。方法:依据药物化学中的拼合原理,设计含有四氢异喹啉母核和阿魏酸结构的四氢异喹啉酰胺类化合物。以取代苯甲酸、胡椒乙胺、乙酰阿魏酸为起始原料,通过酰胺化反应、Bischler-Napieralski反应、水解反应、亲核取代反应等步骤对其进行合成。结果:设计了2个四氢异喹啉酰胺类化合物。按照合成步骤对其进行了合成,2个化合物的结构均经¹H-NMR、¹³C-NMR、MS谱图佐证。结论:设计、合成了2个四氢异喹啉酰胺类化合物,为抗血小板聚集药物开发研究提供参考。更多还原

【Abstract】 Objective: To design and synthesize tetrahydroisoquinoline amide compounds to provide reference for the development of more safe and effective anti platelet aggregation candidate drugs. Methods: According to the principle of drug combination, tetrahydroisoquinoline amide compounds containing tetrahydroisoquinoline mother nucleus and ferulic acid structure were designed. Designed compounds were synthesized by amidation reaction, Bischler napieralski reaction, hydrolysis reaction and nucleophilic substitution reaction. Their starting materials were substituted by benzoic acid, piperonethylamine and acetylferulic acid. Results: Two tetrahydroisoquinoline amide compounds were designed and synthesized. Their structures were confirmed by ¹H-NMR, ¹³C-NMR and MS spectra. Conclusion: Two tetrahydroisoquinoline amide compounds were designed and synthesized, which can provide reference for the development of anti platelet aggregation drugs.更多还原