【摘要】 目的：调查合肥地区2017-2020年成人体检人群高尿酸血症(HUA)患病率变化及其影响因素。方法：选取在某医院体检中心进行健康体检年龄≥18岁的人群共178535例，收集临床资料，检测血常规及生化指标，并进行统计分析。结果：HUA的总体患病率为16.1%，男性高于女性(P<0.001)。无论男、女性，HUA组与SUA正常组合并血脂异常、高血压、eGFR降低、空腹血糖升高的比例存在明显的统计学差异(P<0.001)，HUA组与SUA正常组在SBP、DBP、BMI、WBC、UREA、eGFR、TC、TG、HDL-C、LDL-C、FBG、ALT、AST、DBIL的差异具有统计学意义(P<0.001)。无论男、女性，SUA水平和HUA患病率均随年份变化呈现先降低后升高的趋势。男性HUA患病率在18～69岁各年龄组均高于女性，≥80岁时低于女性(P<0.001)。不同季节间的SUA水平比较差异有统计学意义(P<0.001)，夏秋季的SUA水平和HUA患病率均比春冬季高(P<0.001)，男性高于女性(P<0.001)。男性、高血压、高TC、高TG、高LDL-C、低HDL-C、eGFR降低、WBC、ALT、DBIL是HUA的危险因素，而空腹血糖升高是HUA的保护因素。随着体质量的增加，患HUA的风险逐渐增加。青年男性和老年人更容易患上HUA。结论：合肥地区2017-2020年的HUA患病率总体呈升高趋势，SUA水平季节差异明显，青年男性和老年人患病风险显著增高，应引起足够的重视。更多还原

【Abstract】 Objective:To investigate the change in the prevalence of hyperuricemia (HUA) and its influencing factors in the adult physical examination population in Hefei from 2017 to 2020.Methods:A total of 178,535 cases of people aged≥18 years were selected for health examination at the Physical Examination Center of the Hospital.Clinical data,test blood routine and biochemical indicator are collected and analyzed statistically.Results:The overall prevalence rate of HUA in this study was 16.1%,and males were higher than females (P<0.001).Regardless of male or female,the HUA group and the SUA normal group combined with dyslipidemia,hypertension,eGFR reduction,and fasting plasma glucose increased in the proportion of significant statistical differences(P<0.001).The difference between the HUA group and the SUA normal group in SBP,DBP,BMI,WBC,UREA,eGFR,TC,TG,HDL-C,LDL-C,FPG,ALT,AST,DBILwas statistically significant(P<0.001).Regardless of males or females,the SUA level and HUA prevalence showed a trend of first decreasing and then increasing with the year.The prevalence of HUA in males is higher than that of females in all age groups of 18-69 years,and is lower than that of females at ≥80 years of age (P<0.001).There was a statistically significant difference in SUA levels between different seasons(P<0.001).The SUA level and HUA prevalence in summer and autumn were higher than those in spring and winter (P<0.001),and males were higher than females(P<0.001).Male,hypertension,high TC,high TG,high LDL-C,low HDL-C,decreased eGFR,WBC,ALT,DBIL are risk factors for HUA,while elevated fasting plasma glucose is HUA Protection factor.As weight increases,the risk of developing HUA gradually increases.Young men and the elderly are more likely to develop HUA.Conclusion:The prevalence of HUA in Hefei from 2017 to 2020 shows an overall upward trend.Seasonal differences in SUA levels are obvious.The risk of young men and the elderly is significantly higher,and sufficient attention should be paid.更多还原