【摘要】 目的：探讨乙型肝炎病毒(HBV)相关性慢加急性肝衰竭(HBV-ACLF)患者血清尿酸含量与患者临床预后关系。方法：104例HBV-ACLF患者和112例慢性HBV感染患者为研究对象。比较HBV-ACLF患者和慢性HBV感染患者血清UA含量差异，并分析HBV-ACLF患者UA与TBIL及INR相关性。受试者工作特征曲线评估血清UA预测HBV-ACLF患者住院30天死亡的临床价值。结果：与慢性HBV感染患者相比较，HBV-ACLF患者血清UA含量显著降低(P<0.001)且与TBIL和INR呈显著负相关。与住院30天未死亡患者相比，死亡患者血清UA显著下降(P<0.001)。血清UA预测HBV-ACLF患者住院30天死亡的曲线下面积为0.879。结论：血清UA具有潜在评估HBV-ACLF患者短期预后的临床价值。更多还原

【Abstract】 Objective:To investigate the relationship between serum uric acid level and clinical prognosis in patients with HBV-ACLF.Methods:104 patients with HBV-ACLF and 112 patients with chronic HBV infection were studied.The difference of serum uric acid (UA) concentration in HBV-ACLF patients and chronic HBV infection patients were compared,and relationship between UA,TBIL and INR in HBV-ACLF patients were analysed.The clinical value of serum UA in predicting 30-day hospital death in HBV-ACLF patients was analyzed using receiver operating characteristic curves (ROC).Results:The serum UA level was significantly lower in the HBV-ACLF patients when compared with the chronic HBV infection patients (P<0.001).The significantly negative correlations were found between UA and TBIL and INR (P<0.001) in patients with HBV-ACLF.HBV-ACLF Patients who died within the first 30 days of hospitalization have lower value of serum UA than those who survived (P<0.001).ROC curve analysis showed that the area under the curve of serum UA predicting 30-day death in HBV-ACLF patientswas 0.879.Conclusion:Serum UA has potential clinical value in evaluating the short-term prognosis in HBV-ACLF patients.更多还原