【摘要】 目的探讨血浆25(OH)维生素D水平对冠状动脉旁路移植术(CABG)后新发心房颤动(POAF)的影响。方法选取2017年1月—2019年1月在我院接受CABG的冠心病病人112例作为研究对象,采用单因素和多因素分析25(OH)维生素D对POAF的影响,采用受试者工作特征(ROC)曲线计算25(OH)维生素D预测POAF的临床价值。结果单因素分析显示,POAF和非POAF病人年龄、高血压、糖尿病、C反应蛋白(CRP)、总胆固醇、低密度脂蛋白胆固醇、25(OH)维生素D、左室射血分数比较,差异均有统计学意义(P<0.05)。多因素分析显示,年龄、CRP是POAF发生的危险因素(P<0.05),25(OH)维生素D是POAF发生的保护性因素(P<0.05)。ROC分析显示,25(OH)维生素D预测POAF的灵敏度为0.897,特异性为0.588,截断值为7.75 ng/mL,曲线下面积为0.810。结论血浆25(OH)维生素D水平是POAF发生的保护性因素,低水平的25(OH)维生素D是导致POAF发生的重要原因。更多还原

【Abstract】 Objective To investigate the effect of plasma vitamin D level on atrial fibrillation after coronary artery bypass grafting(CABG).Methods One hundred and twelve patients with coronary heart disease who received CABG in our hospital from January 2017 to January 2019 were selected as the study subjects.The effects of 25(OH) vitamin D on postoperation atrial fibrillation(POAF) were observed by univariate and multivariate analysis,and the clinical value of 25(OH) vitamin D in predicting POAF was calculated using receiver operating characteristic(ROC).Results The univariate analysis showed that there were significant differences in age, hypertension,diabetes,CRP,TC,LDL-C,25(OH) vitamin D,and LVEF between POAF and non-POAF groups(P<0.05).The multivariate analysis showed that age and CRP were risk factors for POAF,and 25(OH) vitamin D was protective factor for POAF(P<0.05).The ROC showed that,the sensitivity was 0.897,specificity was 0.588,cut-off was 7.75 ng/mL,area under the curve was 0.810 of 25(OH) vitamin D in predicting POAF.Conclusion The plasma vitamin D level is a protective factor for POAF, and the low level of vitamin D is an important reason for POAF.更多还原