【摘要】 目的观察不同骨密度（BMD）患者⁹⁹Tc^m-亚甲基二磷酸盐(⁹⁹Tc^m-MDP)骨显像腰椎标准摄取值（SUV）的差异,并分析其与BMD的相关性。方法回顾性分析62例接受⁹⁹Tc^m-MDP全身骨显像、腰椎SPECT/CT断层显像及双能X线腰椎BMD检测患者,根据BMD结果将其分为骨量正常组（n=18）、骨量减低组（n=24）和骨质疏松组（n=20）,比较3组腰椎平均SUV(SUV_mean)、最大SUV(SUV_max)及BMD等的差异,分析其与腰椎平均CT值、患者年龄、体质量及身高的相关性。结果腰椎SUV_max和SUV_mean分别为7.39±1.84和4.90±1.27,均与BMD呈正相关（r=0.64、0.63,P均<0.01）。腰椎SUV_max、SUV_mean和BMD均与年龄呈负相关（r=-0.33、-0.44、-0.43,P均<0.05）,与体质量（r=0.42、0.30、0.35）及平均CT值（r=0.56、0.59、0.73）呈正相关（P均<0.05）,与身高无明显相关（P均>0.05）。3组间腰椎SUV_max、SUV_mean、BMD和平均CT值差异均有统计学意义（F=24.09、30.50、94.85、30.24,P均<0.01）。骨量减低组腰椎SUV_max、SUV_mean、BMD和平均CT值明显低于正常组（P均<0.01）;骨质疏松组明显低于骨量正常组和骨量减低组（P均<0.01）。结论 ⁹⁹Tc^m-MDP骨显像腰椎SUV可用于评价骨质疏松及评估疗效。腰椎SUV_max及SUV_mean均与BMD呈正相关。骨质疏松患者腰椎SUV_max和SUV_mean明显降低。更多还原

【Abstract】 Objective To observe the differences of standard uptake value（SUV）of lumbar vertebrae in ⁹⁹Tc^m-methylene diphosphonate(⁹⁹Tc^m-MDP)bone imaging in patients with different bone mineral density（BMD）,and to analyze the correlation with BMD.Methods Data of 62 patients who underwent ⁹⁹Tc^m-MDP bone imaging,lumbar SPECT/CT imaging and dual energy X-ray BMD examination were retrospectively analyzed.According to BMD,the patients were divided into normal bone mass group（n=18）,bone mass reduction group（n=24）and osteoporosis group（n=20）.The differences of lumbar mean SUV(SUV_mean ),maximum SUV(SUV_max ),BMD and so on were calculated and compared among 3 groups,and the correlations of them and lumbar mean CT value and patient’s,age,weight and height were analyzed.Results SUV_max and SUV_mean of lumbar vertebra were 7.39±1.84 and 4.90±1.27,respectively,both positively correlated with BMD（r=0.64,0.63,all P<0.01）.Statistical differences of lumbar SUV_max ,SUV_mean ,BMD and mean CT values were found among 3 groups（F=24.09,30.50,94.85,30.24,all P<0.01）.SUV_max ,SUV_mean and BMD of lumbar vertebra were all negatively correlated with aging（r=-0.33,-0.44,-0.43,all P<0.05）but positively correlated with body weight（r=0.42,0.30,0.35）and mean CT value（r=0.56,0.59,0.73,all P<0.05）,while not correlated with body height（all P>0.05）.Lumbar SUV_max ,SUV_mean ,BMD and mean CT values of bone mass reduction group were significantly lower than those of normal bone group（all P<0.01）,of osteoporosis group were significantly lower than those of normal bone group and bone mass reduction group（all P<0.01）.Conclusion Lumbar SUV of ⁹⁹Tc^mMDP bone imaging can be used to evaluate osteoporosis and therapeutic effect.SUV_max and SUV_mean of lumbar vertebra are positively correlated with BMD.Lumbar SUV_max and SUV_mean significantly decreased in osteoporosis patients.更多还原