【摘要】 目的 BCAP在介导变应性鼻炎(AR)发病中起着重要作用,其与TGF-β共同深化了AR的病理过程。方法通过采集门诊AR患者20例受试者和对照组6例健康成人的外周血,采用ELISA方法对外周血 BCAP、TGF-β表达水平进行检测,分析探讨这些信号水平与AR及其相互之间的相关性。结果 AR 患者血液中BCAP、TGF-β水平均高于对照组,不过TGF-β和BCAP两者水平无相关关系。结论研究提示了BCAP、TGF-β与AR的发生发展均有较强的关联性,不过两者相对独立,分别受不同的信号通路调控。研究结果可为AR的诊治提供一定的新思路。更多还原

【Abstract】 Objective BCAP plays an important role in the pathogenesis of allergic rhinitis (AR),which,together with TGF-β,deepens the pathological process of AR.Methods By collecting the peripheral blood of 40 outpatients with AR and 12 healthy adults in the control group,the expression levels of BCAP and TGF-β in peripheral blood were detected by ELISA,and the correlation between these signal levels and AR was analyzed.Results The blood levels of BCAP and TGF-β in AR patients were higher than those in the control group,but there was no correlation between the levels of TGF-β and BCAP.Conclusions BCAP,TGF-β and Ar are closely related,but they are independent and regulated by different signaling pathways.The results can provide a new way for the diagnosis and treatment of AR.更多还原