【摘要】 目的:探讨芪苈强心胶囊与曲美他嗪联合应用于老年心力衰竭的临床效果及对血清心肌肌钙蛋白T(cTnT)、心肌酶学、N-末端B型利钠肽原(NT-proBNP)、白介素-6(IL-6)水平的影响。方法:纳入2019年1月-2020年1月本院收治的老年心力衰竭患者100例,随机分为对照组与观察组,每组50例。对照组在常规治疗基础上使用曲美他嗪治疗,观察组在对照组基础上加用芪苈强心胶囊,连续治疗3个月。比较两组治疗前后NT-proBNP、cTnT、IL-6,肌酸磷酸激酶同工酶(CK-MB)、天冬氨酸氨基转移酶(AST)、羟丁酸脱氢酶(HBDH)、乳酸脱氢酶(LDH)、肌酸磷酸激酶(CK)指标水平。结果:观察组总有效率(94.0%)高于对照组(76.0%),差异有统计学意义(P<0.05);两组治疗前NT-proBNP、cTnT、IL-6、CK-MB、AST、HBDH、LDH、CK比较,差异均无统计学意义(P>0.05);两组治疗3个月后CK-MB、AST、HBDH、LDH、CK,cTnT、NT-proBNP、IL-6指标水平均明显降低,且观察组上述指标降低幅度均明显优于对照组(P<0.05)。结论:芪苈强心胶囊与曲美他嗪联合应用于老年CHF治疗,可有效降低心肌细胞损伤,缓解炎症反应性损伤,抑制心肌重构,改善患者心功能及预后,临床疗效较确切。更多还原

【Abstract】 Objective:To explore the clinical effect of Qiliqiangxin Capsule combined with Trimetazidine in the treatment of senile heart failure and its effect on serum cardiac troponin T (cTnT),myocardial enzymology,N-terminal B-type natriuretic peptide (NT-proBNP),interleukin-6 (IL-6).Method:A total of 100 cases of senile heart failure who admitted to our hospital from January 2019 to January 2020,according to the number table method,they were randomly divided into the control group and the observation group,50 cases in each group.The control group was treated with Trimetazidine on the basis of conventional treatment,and the observation group was treated with Qiliqiangxin Capsule on the basis of the control group,two groups were treated for 3 months.The NT-proBNP,cTnT,IL-6,creatine phosphokinase isoenzyme (CK-MB),aspartate aminotransferase (AST),hydroxybutyrate dehydrogenase (HBDH),lactate dehydrogenase (LDH),creatine phosphokinase (CK) levels of two groups before and 3 months after treatment were compared.Result:The total effective rate of the observation group (94.0%) was higher than that of the control group (76.0%),the difference was statistically significant (P<0.05).There were no significant differences in NT-proBNP,cTnT,IL-6,CK-MB,AST,HBDH,LDH and CK levels of two groups before treatment (P>0.05).At 3 months after treatment,there were significant differences in CK-MB,AST,HBDH,LDH,CK,cTnT,NT-proBNP and IL-6 levels were significantly reduced compared with those of before treatment,and the differences were significant (P<0.05).Conclusion:Qiliqiangxin Capsule combined with Trimetazidine in the treatment of senile heart failure can effectively reduce myocardial cell injury,alleviate inflammatory reactive injury,inhibit myocardial remodeling,improve the cardiac function and prognosis of patients,it has a definite clinical effect.更多还原