【摘要】 目的:探究结肠镜联合腹腔镜治疗结直肠癌的效果。方法:选取2017年6月-2019年3月本院收治的结直肠癌患者76例为研究对象,按随机数字表法分为观察组及对照组,各38例。对照组给予传统开腹结直肠癌根治术,观察组给予结肠镜联合腹腔镜治疗术。比较两组患者围手术期指标(手术时间、术后下床活动时间、住院时间);比较术前及术后3 d时两组患者炎症因子[C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)、白介素-6(IL-6)]水平;比较术后3个月时两组患者生活质量[结直肠癌治疗功能评价量表(FACT-C)]、疾病预后情况;比较术后3个月内两组患者并发症发生情况。结果:观察组手术时间、术后下床活动时间、住院时间均显著短于对照组,差异均有统计学意义(P<0.05);术后3 d,两组患者炎症因子水平均较治疗前上升,观察组CRP、TNF-α、IL-6均显著低于同一时间的对照组,差异均有统计学意义(P<0.05);术后3个月,两组患者FACT-C评分均较术前显著提升,观察组均显著高于同一时间对照组,差异均有统计学意义(P<0.05);术后3个月,两组均无死亡病例,两组患者局部复发率、远处转移率比较,差异均无统计学意义(P>0.05);术后3个月内,两组并发症发生率比较,差异无统计学意义(P>0.05)。结论:肠镜联合腹腔镜手术时间短,有利于结直肠癌患者术后恢复,同时可显著抑制患者的炎症因子水平,提升其肛门功能,从而改善其生活质量。更多还原

【Abstract】 Objective:To explore the effect of colonoscopy combined with laparoscopy in the treatment of colorectal cancer.Method:A total of 76 patients with colorectal cancer from June 2017 to March 2019 were selected as the study objects,they were divided into observation group and control group,38 cases in each group,according to the random number table.The control group was treated with traditional open radical operation for colorectal cancer,and the observation group was treated with colonoscopy and laparoscopy.Comparison of perioperative indicators (operation time,postoperative activity time and hospital stay time) between the two groups;inflammatory factor[C-reactive protein (CRP),tumor necrosis factor (TNF-α),and interleukin-6 (IL-6)]were compared between the two groups before and 3 d after surgery;quality of life[colorectal cancer treatment function evaluation scale (FACT-C)]and prognosis of the two groups were compared 3 months after surgery;complications were compared between the two groups within 3 months after operation.Result:The operative time,postoperative activity time and hospital stay time in the observation group were significantly shorter than those in the control group,with statistically significant differences (P<0.05).3 d after the operation,inflammatory factors in both groups increased compared with that before the treatment,CRP,TNF-α and IL-6 in the observation group were significantly lower than those in the control group at the same time,the differences were statistically significant (P<0.05).3 months after surgery,FACT-C scores of both groups were significantly improved compared with those before surgery,and those of the observation group were significantly higher than those of the control group at the same time,with statistically significant differences (P<0.05).3 months after the operation,there was no death case between the two groups,and there were no statistically significant differences in local recurrence rate and distant metastasis rate between the two groups (P>0.05).3 months after the operation,there was no significant difference in the incidence of complications between the two groups (P>0.05).Conclusion:The short duration of colonoscopy combined with laparoscopic surgery is conducive to postoperative recovery of colorectal cancer patients,and can significantly inhibit the level of inflammatory factors in patients,improve their anal function,so as to improve their quality of life.更多还原