【摘要】 自20世纪初,先后暴发了多次威胁人类健康和社会稳定的传染病疫情,如埃博拉出血热、冠状病毒感染引起的严重急性呼吸综合征、中东呼吸综合征和新型冠状病毒肺炎以及寨卡病毒病等。对于尚未表征的新发病原体,尤其是变异速度快、宿主范围广、传播能力强的病毒病原体导致的相关疫情暴发尚无法进行有效预测。目前没有针对上述病毒感染的特效抗病毒药物,接种疫苗是防控疫情最为经济有效的策略。本文对埃博拉病毒、冠状病毒、寨卡病毒的病毒特征以及与之相关的核酸疫苗和病毒载体疫苗技术研究进展做一综述。更多还原

【Abstract】 Since the beginning of this century,diverse infectious diseases that threaten human health and social stability have outbroken,such as Ebola hemorrhagic fever,severe respiratory syndrome caused by coronavirus infection,Middle East respiratory syndrome,COVID-19,and Zika viral disease. For the emerging pathogens that have not been characterized,especially viral pathogens with high mutation rate,wide range of host and strong transmission ability,it is impossible to make an effective prediction of the outbreak by now. At present,there is no specific antiviral drug for the infection of these viruses mentioned above,so vaccination is the most cost-effective strategy for preventing and controlling the epidemic. This review aims at providing an overview of the characteristics of Ebola virus,coronavirus,Zika virus,and the research progress of nucleic acid-based( DNA and m RNA)vaccines and viral vector vaccines to combat the infection of these viruses.更多还原