【摘要】 目的分析叶酸联合维生素B₁₂对高血压伴高同型半胱氨酸（HHcy）血症患者的临床效果。方法 80例高血压伴高同型半胱氨酸血症患者作为研究对象,采用随机数字表法分为研究组和对照组,各40例。对照组患者进行基础治疗,研究组患者在对照组基础上予以叶酸和维生素B₁₂联合治疗。比较两组患者治疗前后血压、血清同型半胱氨酸（Hcy）以及一氧化氮水平。结果治疗前,两组患者收缩压以及舒张压水平比较,差异无统计学意义（P>0.05）;治疗后,研究组患者收缩压（127.3±4.2）mm Hg（1 mm Hg=0.133 kPa）以及舒张压（85.7±6.2）mm Hg均低于对照组的（138.2±4.0）、（94.3±4.2）mm Hg,差异具有统计学意义（P<0.05）。治疗前,两组患者血清同型半胱氨酸以及一氧化氮水平比较,差异无统计学意义（P>0.05）;治疗后,研究组患者血清同型半胱氨酸显著低于对照组,一氧化氮水平明显高于对照组,差异具有统计学意义（P<0.05）。结论高血压伴高同型半胱氨酸血症患者采用叶酸联合维生素B₁₂治疗可改善患者血压、血清同型半胱氨酸以及一氧化氮水平。更多还原

【Abstract】 Objective To analyze the clinical effect of folic acid combined with vitamin B₁₂ on hypertension patients with hyperhomocysteinemia（HHcy）. Methods A total of 80 cases of hypertension patients with hyperhomocysteinemia as study subjects as study subjects were divided into research group and control group according to random numerical table, with 40 cases in each group. The control group was treated with basic therapy, and the research group was treated with folic acid combined with vitamin B₁₂ on the basis of the control group. The blood pressure, serum homocysteine（Hcy） and nitric oxide levels before and after treatment were compared between the two groups. Results Before treatment, there was no statistically significant difference in systolic blood pressure and diastolic blood pressure between the two groups（P>0.05）. After treatment, the systolic blood pressure（127.3±4.2） mm Hg（1 mm Hg=0.133 k Pa） and diastolic blood pressure（85.7±6.2） mm Hg of the research group were lower than（138.2±4.0） and（94.3±4.2） mm Hg of the control group, and the difference was statistically significant（P<0.05）. Before treatment, there was no statistically significant difference in serum homocysteine and nitric oxide levels between the two groups（P>0.05）. After treatment, the serum homocysteine of the research group was significantly lower than that of the control group, and nitric oxide was obviously higher than that of the control group, and the difference was statistically significant（P<0.05）. Conclusion Folic acid combined with vitamin B₁₂ can improve the blood pressure, serum homocysteine and nitric oxide levels of hypertension patients with hyperhomocysteinemia.更多还原