【摘要】 目的探讨神经内镜经鼻蝶手术切除无功能性垂体腺瘤(nonfunctioning pituitary adenoma,NFPA)的临床疗效。方法回顾性分析104例NFPA病人的临床资料,均行神经内镜下经鼻蝶手术切除肿瘤,分析手术疗效。结果肿瘤全切除87例,次全切除9例,部分切除8例。术后发生脑脊液鼻漏5例,一过性尿崩症28例,鼻出血4例,颅内感染3例。81例随访6～48个月,术后头痛缓解率97.4%,视力改善率85.2%,视野改善率76.7%,多数病人激素水平不同程度恢复。肿瘤复发2例。结论NFPA神经内镜下经鼻蝶手术具有较高的有效性和安全性,是NFPA的首选治疗方法,术后需长期随访。更多还原

【Abstract】 Objective To investigate the clinical efficacy of neuroendoscopic transnasal transsphenoidal surgery for nonfunctional pituitary adenomas(NFPA). Methods Clinical data of 104 patients with NFPA undergoing neuroendoscopic transnasal transsphenoidal surgery were analyzed retrospectively. Then, the surgical outcome was analyzed. Results Total tumor resection was achieved in 87 patients, subtotal resection in 9 and partial resection in 8. The postoperative complication included 5 cerebrospinal fluid rhinorrhea, 28 transient diabetes insipidus, 4 nosebleeds and 3 intracranial infection. Eighty-one patients were followed up for 6 to 48 months, the remission rate of headache, vision and visual field were 97.4%, 85.2% and 76.7% respectively. The levels of hormone recovered in different degree in most patients, and the tumor recurred in 2 patients. Conclusions Endoscopic transnasal transsphenoidal surgery is highly effective and safe, and the preferred treatment for NFPA. Long-term follow-up is required after surgery.更多还原