【摘要】 目的从循证医学角度分析尿路感染与原发性胆汁性胆管炎(primary biliary cholangitis,PBC)的相关性。方法检索并筛选PubMed、Embase、Web of Science、Cochrane library、万方数据库、维普数据库及中国知网有关尿路感染与PBC的文献,采用Review manager 5.3进行meta分析。结果共纳入7篇文献,PBC组有4 197例,其中有尿路感染1 538例;对照组有21 237例,其中5 092例有尿路感染病史。meta结果显示PBC组比对照组尿路感染发生率增高(OR:1.50,95%CI:1.26～1.77,P<0.01)。按地区进行亚组分析,北美地区PBC人群OR值为1.34,95%CI:1.23～1.46,P<0.01,欧洲地区的OR值为1.79,95%CI:1.37～2.33,P<0.01。结论 PBC人群中尿路感染发生风险高于一般人群,需设计更严谨的临床研究证明两者之间因果关系。更多还原

【Abstract】 Objective To systematically investigate relationship between the urinary tract infections and PBC from the perspective of evidence-based medicine.Methods PubMed,Embase,Web of Science,Cochrane library,China National Knowledge Infrastructure,Wangfang Database and VIP database were searched to for observational studies on association between association between the urinary tract infections and PBC.And then a meta-analysis was performed by using Review manager 5.3 software.Results A total of 7 studies involving 4197 cases of PBC group and 21237 cases of control group.There were 1538 patients with urinary tract infection in PBC group and 4197 patients in control group.A random effect model was used for overall analysis based on heterogeneity.The results showed that the incidence of urinary tract infections in the PBC group is higher compared with the control group(OR=1.50,95% CI:1.26 to 1.77,P<0.00001).By subgroup analysis by region,PBC group had significant increasing risk of UTIs compared to the control group in both North America(OR:1.34,95%CI:1.23 to 1.46,P<0.00001)and European(OR:1.79,95%CI:1.37 to 2.33,P<0.0001).Conclusion The risk of UTIs is higher in the PBC group than the control group.However,more rigorous clinical studies need to be designed to prove the causal relationship.更多还原